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A Study of Antolimab (AK002) in Patients With Active Eosinophilic Esophagitis (KRYPTOS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04322708
Recruitment Status : Recruiting
First Posted : March 26, 2020
Last Update Posted : August 4, 2020
Sponsor:
Information provided by (Responsible Party):
Allakos, Inc.

Brief Summary:
This is a Phase 2/3, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of antolimab (AK002) given monthly for 6 doses in adult and adolescent patients with active eosinophilic esophagitis. Subjects who complete the randomized, double-blind, placebo-controlled treatment may have the option to receive 6 doses of open-label antolimab (AK002) through the OLE Period of the study.

Condition or disease Intervention/treatment Phase
Eosinophilic Esophagitis Other: Placebo Drug: antolimab (AK002) Phase 2 Phase 3

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 300 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Antolimab (AK002) in Adult and Adolescent Patients With Active Eosinophilic Esophagitis
Actual Study Start Date : July 6, 2020
Estimated Primary Completion Date : December 2021
Estimated Study Completion Date : May 2022

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Placebo Comparator: Placebo
Subjects in this arm will receive 6 monthly doses of placebo.
Other: Placebo
Placebo

Experimental: 1 mg/kg of antolimab (AK002)
Subjects in this arm will receive 6 monthly doses of antolimab (AK002) (1mg/kg).
Drug: antolimab (AK002)
Antolimab (AK002) is a humanized non-fucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against Siglec-8.

Experimental: 3 mg/kg of antolimab (AK002)
Subjects in this arm will receive 6 monthly doses of antolimab (AK002): A first dose of 1 mg/kg, followed by 5 monthly doses of 3 mg/kg.
Drug: antolimab (AK002)
Antolimab (AK002) is a humanized non-fucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against Siglec-8.




Primary Outcome Measures :
  1. The proportion of patients who achieve esophageal intraepithelial eosinophil count of ≤6 eosinophils/hpf [ Time Frame: At Week 24 ]
  2. Mean absolute change in Dysphagia Symptom Questionnaire (DSQ) score [ Time Frame: Baseline to Weeks 23-24 ]

Secondary Outcome Measures :
  1. Percent change in esophageal intraepithelial eosinophil count [ Time Frame: Baseline to Week 24 ]
  2. Proportion of patients achieving esophageal intraepithelial eosinophil count of ≤1 eosinophil/hpf [ Time Frame: At Week 24 ]
  3. Proportion of patients achieving esophageal intraepithelial eosinophil count of ≤15 eosinophil/hpf [ Time Frame: At Week 24 ]
  4. Proportion of treatment responders when a responder is a patient achieving >30% reduction in symptoms (DSQ) and achieving a peak intraepithelial eosinophilic count of ≤6 eosinophils/hpf [ Time Frame: At Weeks 23-24 ]
  5. Proportion of patients with >50% reduction in DSQ score [ Time Frame: Baseline to Weeks 23-24 ]
  6. Percent change in DSQ score [ Time Frame: Baseline to Weeks 23-24 ]
  7. Change in biweekly mean DSQ over time. [ Time Frame: Baseline to Weeks 23-24 ]
  8. Absolute change in EoE Reference Score for Endoscopic Abnormalities (EREFS) [ Time Frame: Baseline to Week 24 ]


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Ages Eligible for Study:   12 Years to 80 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Key Inclusion Criteria:

  1. Male or female aged ≥12 and ≤80 years at the time of signing ICF.
  2. Confirmed diagnosis of EoE and esophageal intraepithelial eosinophilic infiltration of ≥15 eosinophils/hpf in 1 hpf from a biopsy collected during the Screening EGD without any other cause for the esophageal eosinophilia.
  3. History (by patient report) of an average of ≥2 episodes of dysphagia with intake of solid foods per week during the 4 weeks prior to Screening.
  4. Subjects must have failed or not be adequately controlled on standard of care treatments for EoE symptoms, which could include PPI, systemic or topical corticosteroids, and/or diet, among others.
  5. If on an allowed treatment for EoE, stable dose for at least 4 weeks prior to Screening and willingness to continue that dose for the study duration.
  6. If patient is on pre-existing dietary restrictions, willingness to maintain dietary restrictions throughout the study, as much as possible.
  7. Able and willing to comply with all study procedures.
  8. Female subjects must be either post-menopausal for at least 1 year with FSH level >30 mIU/mL at Screening or surgically sterile (tubal ligation,hysterectomy, or bilateral oophorectomy) for at least 3 months, or if of childbearing potential, have a negative pregnancy test and agree to use dual methods of contraception, or abstain from sexual activity from screening until the end of the study, or for 120 days following the last dose of study drug, whichever is longer. Male subjects with female partners of childbearing potential must agree to use a highly effective method of contraception from Screening until the end of the study or for 120 days following the last dose of study drug,whichever is longer. All fertile men with female partners of childbearing potential should be instructed to contact the Investigator immediately if they suspect their partner might be pregnant at any time during study participation.

Key Exclusion Criteria:

  1. Concomitant EG, EoD, or eosinophilic colitis (EC).
  2. EG and/or EoD (≥30 eosinophils/hpf in 5 hpf in the stomach and/or ≥30 eosinophils/hpf in 3 hpf in the duodenum) as determined by central histology assessment of biopsies collected during the Screening EGD.
  3. Causes of esophageal eosinophilia other than EoE or one the following: hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, or peripheral blood absolute eosinophil count of >1500 eosinophils/μL.
  4. History of inflammatory bowel disease, celiac disease, achalasia, and/or esophageal surgery.
  5. Any esophageal stricture unable to be passed with a standard diagnostic 9 mm to 10 mm upper endoscope or any critical esophageal stricture that requires dilation during screening.
  6. History of bleeding disorders or esophageal varices.
  7. History of malignancy; except carcinoma in situ, early stage prostate cancer, or non-melanoma skin cancers. However, cancers that have been in remission for more than 5 years and are considered cured, can be enrolled (with the exception of breast cancer). All history of malignancy (including diagnosis, dates, and compliance with cancer screening recommendations) must be documented and certified by the Investigator, along with the statement that in their clinical judgment the tissue eosinophilia is attributable to EGID, rather than recurrence of malignancy.
  8. Active Helicobacter pylori infection (as determined by central histology staining of the biopsy collected during the Screening EGD), unless treated and confirmed to be negative prior to randomization and symptoms remain consistent.
  9. Positive Ova and Parasite (O&P) test at Screening, seropositive for Strongyloides stercoralis at Screening, and/or treatment for a clinically significant helminthic parasitic infection within 6 months of Screening.
  10. Seropositive for HIV or hepatitis at Screening, except for vaccinated patients or patients with a history of hepatitis that has since resolved.
  11. Prior exposure to AK002 or hypersensitivity to any constituent of AK002.
  12. Change in dose of inhaled corticosteroids, nasal corticosteroids, PPI, and/or diet therapy within 4 weeks prior to Screening.
  13. Use of oral corticosteroids (swallowed topical or systemic corticosteroids) within 8 weeks prior to Screening.
  14. Use of any biologics or medications that may interfere with the study, such as immunosuppressive or immunomodulatory drugs including azathioprine, JAK inhibitors, 6-mercaptopurine, methotrexate, cyclosporine, tacrolimus, anti-TNF, anti-IL-4 receptor, e.g., dupilumab), anti-IL-5 (e.g., mepolizumab), anti-IL-5 receptor (e.g., benralizumab), anti-IL-13 (e.g., lebrikizumab), anti-IgE (e.g., omalizumab), within 12 weeks prior to Screening.
  15. Participation in a concurrent interventional study with the last intervention occurring within 30 days prior to administration of study drug or 90 days or 5 half-lives, whichever is longer, for biologic products.
  16. Vaccination with live attenuated vaccines ≤30 days prior to initiation of treatment in the study, during the treatment period, or vaccination expected ≤5 half-lives (≤4 months) following study drug administration.
  17. Treatment with chemotherapy or radiotherapy in the preceding 6 months.
  18. Presence of abnormal laboratory values considered by the Investigator to be clinically significant.
  19. Any disease, condition (medical or surgical), or cardiac abnormality, which in the opinion of the Investigator, would place the subject at increased risk.
  20. Known history of alcohol, drug, or other substance abuse or dependence.
  21. Women who are pregnant, breastfeeding, or planning to become pregnant while participating in the study.
  22. Any other reason that in the opinion of the Investigator or Medical Monitor makes the patient unsuitable for enrollment.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04322708


Contacts
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Contact: Henrik Rasmussen, MD, PhD 443-699-5230 hrasmussen@allakos.com

Locations
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Sponsors and Collaborators
Allakos, Inc.
Investigators
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Study Director: Henrik Rasmussen, MD, PhD Allakos, Inc.
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Responsible Party: Allakos, Inc.
ClinicalTrials.gov Identifier: NCT04322708    
Other Study ID Numbers: AK002-014
First Posted: March 26, 2020    Key Record Dates
Last Update Posted: August 4, 2020
Last Verified: August 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Allakos, Inc.:
EoE
Eosinophil
Esophagitis
Additional relevant MeSH terms:
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Esophagitis
Eosinophilic Esophagitis
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Gastroenteritis
Eosinophilia
Leukocyte Disorders
Hematologic Diseases
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases