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Phase 2 Study of Tanezumab in Subjects With Moderate to Severe Pain Due to Schwannomatosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04163419
Recruitment Status : Not yet recruiting
First Posted : November 14, 2019
Last Update Posted : December 10, 2019
Sponsor:
Collaborator:
Pfizer
Information provided by (Responsible Party):
Scott R. Plotkin, MD, PhD, Massachusetts General Hospital

Brief Summary:
The primary objective of this study is to determine whether the administration of tanezumab, an anti-nerve growth factor (NGF) antibody, improves pain relief in schwannomatosis patients receiving background non-NSAID therapy.

Condition or disease Intervention/treatment Phase
Schwannomatosis Pain Drug: Tanezumab Drug: Placebo Phase 2

Detailed Description:

Schwannomatosis is characterized by the predisposition to develop multiple schwannomas and, less commonly, meningiomas. Pain is the most frequent symptom reported by these patients, with 68% experiencing chronic pain.

The investigators propose to test the efficacy and tolerability of tanezumab as a treatment for schwannomatosis patients with chronic pain who have had inadequate pain relief in a randomized, placebo-controlled trial, which could form the basis of a larger, randomized controlled trial in the future.

The study is designed with a total duration of 281 days (40 weeks) and will consist of four periods: Pre-treatment, Double-Blind Treatment, Single Arm Treatment, and 24-Week Safety Follow-up. The Pre-Treatment Period lasting up to 30 days, followed by a Double-Blind Treatment Period lasting up to 8 weeks, followed by a Single Arm Treatment Period lasting up to 8 weeks, and a 24-Week Safety Follow-Up Period ending with the End of Study Visit at Week 40.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 46 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Phase 2 Randomized, Double-blind, Placebo-Controlled Study of the Analgesic Efficacy and Safety of the Subcutaneous Administration of the Anti-NGF Antibody Tanezumab in Subjects With Moderate to Severe Pain Due to Schwannomatosis
Estimated Study Start Date : February 2020
Estimated Primary Completion Date : June 2023
Estimated Study Completion Date : June 2024


Arm Intervention/treatment
Experimental: Arm A (treatment)
Tanezumab 10 mg SC administered on day 1 and Day 57 (± 4 days)
Drug: Tanezumab
Tanezumab 10 mg SC
Other Name: PF-04383119

Placebo Comparator: Arm B (placebo then treatment)
Placebo SC (to match tanezumab SC) administered on Day 1 and tanezumab 10 mg SC on Day 57 (± 4 days)
Drug: Tanezumab
Tanezumab 10 mg SC
Other Name: PF-04383119

Drug: Placebo
Placebo 10 mg SC




Primary Outcome Measures :
  1. Change in pain level [ Time Frame: 8 weeks ]
    Change in worst pain level during past week from baseline to week 8 measured by NRS-11


Secondary Outcome Measures :
  1. Frequency of AEs [ Time Frame: 40 weeks ]
    Frequency of AEs related to treatment with Tanezumab

  2. Incidence of orthostatic hypotension [ Time Frame: 40 weeks ]
    Incidence of orthostatic hypotension using postural changes in blood pressure in addition to mean changes in postural blood pressure



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients must have a confirmed diagnosis schwannomatosis by fulfilling either clinical or molecular diagnosis.
  2. Age ≥ 18 years. Patients < 18 years are excluded since the safety profile of tanezumab in this population has not been determined.
  3. ECOG performance status ≤2 or Karnofsky ≥60%
  4. Participants must have normal organ and marrow function as defined per the full protocol
  5. The subject's weight must be≥ 45 kg at Screening.
  6. The subject must be willing to avoid prohibited pain medications (including non-steroidal anti-inflammatory drugs) throughout the duration of the study except as permitted per Protocol.
  7. Subject must have moderate to severe pain secondary to schwannomatosis, defined as Score ≥5 on the Numeric Rating Scale-11 (NRS-11) at Screening.
  8. Subject must have failure, intolerance, or contraindication to at least three standard of care therapies:

    • Documented history indicating that NSAID therapy has not provided adequate pain relief or subject is unable to take NSAIDs due to contraindication or inability to tolerate.
    • Documented history indicating that opioid treatment has not provided adequate pain relief or subject is unwilling to take opioids, or unable to take opioids due to contraindication or inability to tolerate
    • Documented history indicating that neuropathic pain medications, such as gabapentin, pregabalin, or others, have not provided adequate pain relief or subject is unable to take these treatments due to contraindication or inability to tolerate.
  9. Female subjects of childbearing potential and at risk for pregnancy (e.g., not abstinent) must agree to use 2 highly effective methods of contraception throughout the study and for 112 days (16 weeks) after the last dose of assigned subcutaneous study medication.

Exclusion Criteria:

  1. Subjects with any of the following criteria: evidence of bilateral vestibular schwannomas on imaging, a known germline pathogenic NF2 mutation, a first-degree relative who meets diagnostic criteria for NF2, or have schwannomas limited to a previous radiation field.
  2. Subjects with intracranial meningioma associated with cerebral edema on neuroimaging. Note: presence of intracranial meningioma itself is not an exclusion criterion.
  3. Subjects who have had surgery, chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) for treatment of a painful schwannomatosis-related tumor prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
  4. Participation in other studies involving investigational drug(s) (Phases 1-4) within 30 days (or 90 days for biologics) before Screening and/or during study participation.
  5. Subjects receiving anticoagulation to treat an underlying medical condition.
  6. Subject has a history of allergic or anaphylactic reaction to a therapeutic or diagnostic monoclonal antibody or IgG fusion protein.
  7. The subject's pain is related to a non-schwannomatosis cause such as prior cancer therapy, infection, bowel obstruction/perforation, spinal cord compression, or fracture or impending fracture of weight bearing bone.
  8. The subject has a diagnosis of malignancy in the last 3 years (except for Gleason 6 prostate cancer, basal cell carcinoma or carcinoma in situ).
  9. Use of concurrent adjuvant analgesics such as serotonin norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants, anticonvulsant medication, or muscle relaxants (unless the drugs were started at least 30 days prior to Screening and are maintained at a stable dose).
  10. Use of concurrent analgesic non-steroidal anti-inflammatory drugs (NSAIDs, including selective COX-2 inhibitors) unless the subject is expected to be able to discontinue these medications at least 2 weeks prior to treatment. Note: Subjects who take daily low dose aspirin (≤ 325 mg as per local prescribing practice) therapy for cardiovascular prophylaxis are not excluded from participation.
  11. Diagnosis of osteoarthritis of the knee or hip as defined by the American College of Rheumatology (ACR) combined clinical and radiographic criteria; Radiographic criteria will be assessed by the Central Reader.
  12. Use of concurrent corticosteroids (except for inhaled or topical corticosteroids as needed for management of ongoing pulmonary or dermatologic conditions)
  13. Subjects considered unfit for surgery, defined as Grade >3 on the American Society of Anesthesiologists (ASA) physical classification system for surgery or subjects who would not be willing to undergo joint replacement surgery if required.
  14. Subjects with symptoms and radiographic findings (i.e. joint space narrowing, osteophytes) consistent with osteoarthritis in the shoulder.
  15. History of significant trauma or surgery to a major joint (e.g. hip, knee or shoulder) within one year prior to Screening.
  16. A history of osteonecrosis or osteoporotic fracture (i.e., a subject with a history of osteoporosis and a minimally traumatic or atraumatic fracture).
  17. Radiographic (x-ray) evidence of any of the following conditions as determined by the central radiology reviewer at Screening: 1) rapidly progressive osteoarthritis, 2) atrophic or hypotrophic osteoarthritis, 3) subchondral insufficiency fracture, 4) spontaneous osteonecrosis of the knee (SPONK), 5) osteonecrosis, or 6) pathologic fracture.
  18. Subjects who have evidence of orthostatic hypotension based upon replicate orthostatic blood pressure measurements at Screening.
  19. Subjects with a total impact score of >7 on the Survey of Autonomic Symptoms (SAS) at Screening.
  20. Diagnosis of a transient ischemic attack in the 6 months prior to Screening or diagnosis of stroke with residual deficits (e.g., aphasia, substantial motor or sensory deficits), that would preclude completion of required study activities.
  21. History, diagnosis, or signs and symptoms of clinically significant neurological
  22. Subjects with a past history of carpal tunnel syndrome (CTS) with signs or symptoms of CTS in the one year prior to Screening.
  23. Subject with a history of significant alcohol, analgesic, or narcotic substance abuse within the six months prior to Screening.
  24. Subject who, in the judgement of the investigator, is expected to require a surgical procedure during the duration of the study.
  25. Previous exposure to exogenous nerve growth factor or to an anti-nerve growth factor antibody.
  26. Subjects who are investigational site staff members directly involved in the conduct of the trial and their family members, site staff members otherwise supervised by the Investigator, or subjects who are Pfizer employees directly involved in the conduct of the trial
  27. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  28. Pregnant females; breastfeeding females; females of childbearing potential not using two (2) methods of highly effective contraception or not agreeing to continue two (2) methods of highly effective contraception for 112 days (16 weeks) after last dose of investigational product.
  29. Any subject who, in the judgement of the investigator, is deemed inappropriate for participation in the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04163419


Contacts
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Contact: Scott R Plotkin, MD, PhD 617-726-3650 splotkin@mgh.harvard.edu

Locations
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United States, Massachusetts
Massachusetts General Hospital Not yet recruiting
Boston, Massachusetts, United States, 02114
Principal Investigator: Scott R. Plotkin, MD, PhD         
Sponsors and Collaborators
Massachusetts General Hospital
Pfizer
Investigators
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Principal Investigator: Scott R Plotkin Massachusetts General Hospital

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Responsible Party: Scott R. Plotkin, MD, PhD, Professor of Neurology, Massachusetts General Hospital
ClinicalTrials.gov Identifier: NCT04163419    
Other Study ID Numbers: 2019P003201
First Posted: November 14, 2019    Key Record Dates
Last Update Posted: December 10, 2019
Last Verified: December 2019

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Scott R. Plotkin, MD, PhD, Massachusetts General Hospital:
schwannoma
nerve growth factor
antibody
NGF
Additional relevant MeSH terms:
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Neurilemmoma
Skin Neoplasms
Neurofibromatoses
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neuroma
Nerve Sheath Neoplasms
Neoplasms, Nerve Tissue
Neoplasms by Site
Skin Diseases
Neurofibroma
Neoplastic Syndromes, Hereditary
Neurocutaneous Syndromes
Nervous System Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Tanezumab
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents