Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
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|ClinicalTrials.gov Identifier: NCT04117321|
Recruitment Status : Recruiting
First Posted : October 7, 2019
Last Update Posted : October 14, 2019
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations.
The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders.
Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.
|Condition or disease|
|Gut Microbiome Mother to Child Transmission|
|Study Type :||Observational|
|Estimated Enrollment :||20000 participants|
|Official Title:||Mother-infant Microbiota Transmission and Its Link to the Health of the Baby|
|Actual Study Start Date :||September 23, 2019|
|Estimated Primary Completion Date :||October 2, 2026|
|Estimated Study Completion Date :||October 2, 2027|
Women who are being pregnant and plan to give birth in local hospital. Pregnant women who plan to stay in the same local area for at least 7 years post-delivery.
New Born Baby
new born baby of an enrolled pregnant woman.
Father of new born baby
Biological father of an enrolled new born baby.
- Develop a 100,000 pair of mother-baby longitudinal cohort [ Time Frame: 8 year ]Set up a large scale database to collect data such as comprehensive clinical data, such as mother's and father's demographic and clinical information (e.g. age, weight, gender, family medical history, dietary, drug usage etc.)
- Dissect the important microbiome that maintain health [ Time Frame: 8 year ]Study samples will be collected to characterize which microbiota will be transmitted from mother to baby by performing metagenomics of gut microbiome in stool and other samples
- Seize the golden period of early life for prevention of human diseases [ Time Frame: 8 year ]Study samples will be collected to characterize which microbiota induces disease by performing metagenomics of gut microbiome in stool and other samples and develop treatment with microbiota.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04117321
|Contact: Jessica Ching||+852 firstname.lastname@example.org|
|Contact: Kitty Cheung||+852 email@example.com|
|China, Hong Kong|
|Prince of Wales Hospital||Recruiting|
|Hong Kong, Hong Kong, China|
|Contact: Francis KL Chan, MD 85226323143|