Pityriasis Lichenoides : Anatomo-clinical Aspects and Follow-up (EtudePL)
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|ClinicalTrials.gov Identifier: NCT03920696|
Recruitment Status : Unknown
Verified February 2019 by Assistance Publique - Hôpitaux de Paris.
Recruitment status was: Not yet recruiting
First Posted : April 19, 2019
Last Update Posted : April 19, 2019
Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state.
The current classification is confusing because it mixes semiological and chronological notions.
The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population.
Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed.
Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||52 participants|
|Official Title:||Pityriasis Lichenoides: Anatomo-clinical Aspects and Follow-up Monocentric Retrospective Study|
|Estimated Study Start Date :||May 1, 2019|
|Estimated Primary Completion Date :||November 1, 2019|
|Estimated Study Completion Date :||November 1, 2019|
- To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients [ Time Frame: It will be measured within 6 months of enrollment ]Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.
- To study histological features of Pityriasis Lichenoides [ Time Frame: It will be measured within 6 months of enrollment ]The histological description will make use of a centralized re-reading of the slides according to a standardized grid (appearance of the epidermis, type and topography of the dermal infiltrate, results of the immunolabelings etc ...). The investigators aim to investigate the frequency of patients with patterns of pityriasis lichenoides mimicking lymphomatoid papulosis or mycosis fungoides and to correlate the histological aspect with clinical lesions.
- To study molecular features of Pityriasis Lichenoides [ Time Frame: It will be measured within 6 months of enrollment ]number of clone T in the skin and in the blood.
- To study the treatment during patients' monitoring [ Time Frame: It will be measured within 6 months of enrollment ]number of patients with need of a prolonged treatment
- To study the duration of outbreak during patients' monitoring [ Time Frame: It will be measured within 6 months of enrollment ]the time to healing
- To study the relapse during patients' monitoring [ Time Frame: It will be measured within 6 months of enrollment ]the number of relapses
- To study the number of outbreaks during patients' monitoring [ Time Frame: It will be measured within 6 months of enrollment ]the number of outbreaks
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03920696
|Contact: Saskia ORO, Doctor||+33 1 49 81 25 firstname.lastname@example.org|
|Principal Investigator:||Saskia ORO, Doctor||Assistance Publique Hôpitaux de Paris - CHU Henri Mondor - Créteil|