Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)
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|ClinicalTrials.gov Identifier: NCT03823794|
Recruitment Status : Active, not recruiting
First Posted : January 30, 2019
Last Update Posted : March 13, 2019
Atopic dermatitis, commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used.
Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently. This study aims to provide accurate estimates of the number of people with current eczema (prevalence), number developing new onset eczema (incidence), and the pattern of common comorbidities in people with eczema. It also aims describe current treatment patterns by age groups and other factors. It also will look back over the last decade to identify how the number of people with eczema and treatments changing over time. The study will also explore patterns in the people most commonly affected and in the treatments used.
|Condition or disease||Intervention/treatment|
|Atopic Dermatitis Eczema Atopic Dermatitis Eczema||Other: No intervention|
This study aims to calculate current and accurate prevalence and incidence estimates for atopic dermatitis (AD) by age group and sociodemographic factors. It also aims to describe the burden of comorbidity in AD with a focus on atopic and mental health conditions. The study also aims to describe the health care resource utilisation of this cohort in terms of prescription use, primary care appointments, and specialist referrals.
Method This study will define AD cases using a previously validated algorithm for case identification use clinical codes form primary care in the UK (Read codes). The study will analyse the population prevalence and incidence of AD using this definition over a 10-year period (2008-2018). Within this population the prevalence of autoimmune conditions (rheumatoid arthritis, inflammatory bowel disease, coeliac disease, type 1 diabetes, and multiple sclerosis) will be reported and compared with a cohort of individuals without a diagnosis of AD, matched by age and sex at GP practice level. In the same cohort, the annual use of topical and oral medications used for the treatment of AD, primary care appointments, and specialist referrals, overall and stratified by sociodemographic factors will also be reported.
|Study Type :||Observational|
|Estimated Enrollment :||200000 participants|
|Official Title:||The Epidemiology of Atopic Dermatitis, Associated Comorbidities, and Treatment Patterns in the United Kingdom (UK)|
|Actual Study Start Date :||February 1, 2019|
|Estimated Primary Completion Date :||August 1, 2019|
|Estimated Study Completion Date :||November 1, 2019|
Prevalent case of atopic dermatitis
People with atopic dermatitis meeting the inclusion criteria and registered with one of the study practices for one or more years during the study period.
Other: No intervention
Observational analysis of usual care only
Age, gender and primary care practice-matched controls without a diagnosis of atopic dermatitis or another exclusion condition (psoriasis, photodermatitis, or ichthyosis) and registered with one of the study practices for one or more years during the study period.
Other: No intervention
Observational analysis of usual care only
- The incidence of atopic dermatitis [ Time Frame: Measure will be reported annually by year from 2008-2018 ]Incidence of atopic dermatitis reported by predefined sociodemographic factors
- The prevalence of atopic dermatitis [ Time Frame: Measure will be reported annually by year from 2008-2018 ]Prevalence of atopic dermatitis reported by predefined sociodemographic factors
- The prevalence of diagnosed co-morbidities in people with and without atopic dermatitis [ Time Frame: Prevelence reported annually by year from 2008-2018 ]Co-morbidities to be reported comprise; asthma, allergic rhinitis (hay fever), depression, anxiety, attention deficit hyperactivity disorder (ADHD), cardiovascular diseases (CVD; comprising myocardial infarction, angina, heart failure, atrial fibrillation, and stroke), rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn's disease), type 1 and type 2 diabetes, multiple sclerosis (MS) and coeliac disease. The presence of these co-morbidities will be identified from existing primary care records.
- Annual rates of service utilisation (number of primary and secondary care visits) in people with atopic dermatitis [ Time Frame: Measures will be reported annually by year from 2008-2018 ]Service utilisation events comprise; primary care visits related to atopic dermatitis (prescription of treatment or coding of AD related problem), specialist care referrals to dermatology, and emergency admissions to dermatology. These events will also be reported separately.
- Annual prescription rates for atopic dermatitis related treatments [ Time Frame: Measures will be reported annually by year from 2008-2018 ]Treatment rates will be reported separately and comprise: emollients and soap substitutes, topical steroids, topical antimicrobial therapies, combination topical therapies, topical calcineurin inhibitors, and oral immune modulating treatments, and phototherapy.
- Time to occurrence of moderate atopic dermatitis [ Time Frame: Models will be devised using data from 2008-2018 ]The impact of sociodemographic predictors on time to first occurrence of moderate atopic dermatitis
- Time to occurrence of severe atopic dermatitis [ Time Frame: Models will be devised using data from 2008-2018 ]The impact of sociodemographic predictors on time to first occurrence of severe atopic dermatitis
- Time to recurrence of active atopic dermatitis [ Time Frame: Models will be devised using data from 2008-2018 ]The impact of sociodemographic predictors on time to first recurrence of atopic dermatitis in those with inactive disease
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03823794
|Momentum Data Ltd|
|London, United Kingdom, WC1X 8QT|