Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Know the risks and potential benefits of clinical studies and talk to your health care provider before participating.
Read our disclaimer for details.
single institution cases series review of histological and clinical data
Condition or disease
Angiomatoid Fibrous Histiocytoma
single institution cases series review of histological and clinical data Investigators will retrieve from the archives of the Rizzoli Institute all the cases with a histological diagnosis of Angiomatoid Fibrous Histiocytoma. In all cases with enough available material, immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material.
selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma [ Time Frame: at baseline (Day0) ]
investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.
analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material [ Time Frame: at baseline (Day0) ]
In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.
Biospecimen Retention: Samples Without DNA
immunohistochemistry will be performed on FFPE material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Male and Female with diagnosis of Angiomatoid Fibrous Histiocytoma with histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis
Male and female patients treated at Rizzoli Institute from 01 January 2006 to 31 December 2017
Diagnosis of Angiomatoid Fibrous Histiocytoma
Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis
Written informed consent prior to any study-specific analysis and/or data collection
• Patients with histological diagnosis different from Angiomatoid Fibrous Histiocytoma