TSHβX1 and D2 THR92ALA in Pregnancy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03612908|
Recruitment Status : Completed
First Posted : August 2, 2018
Last Update Posted : August 2, 2018
|Condition or disease|
|Pregnancy Related Hypothyroidism Hyperthyroidism|
Deiodinase 2 (DIO2) is a selenoenzyme responsible for the deiodination of T4 to T3, which makes it crucial for the proper functioning of thyroid hormones. Polymorphisms of DIO2 alters the enzymatic function. In addition, the Ala92Ala genotype was reported to be related with a reduction in the placental activity of D2, which could worsen gestational complications.
In the other hand, the TSHβ gene (NC_000001.11) located on chromosome 1 at position 38p12, codes for the beta unit of the thyroid stimulating hormone (TSH). It is admitted that genetic variants can show a different spectrum of actions.
This was a clinical, comparative, prospective and transversal study. Pregnant women aged 18-44 years old, were invited to identify it they had a DIO2 polymorphism or the TSHβX1 splice variant.
|Study Type :||Observational|
|Actual Enrollment :||96 participants|
|Official Title:||TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases|
|Actual Study Start Date :||September 1, 2016|
|Actual Primary Completion Date :||December 15, 2017|
|Actual Study Completion Date :||June 30, 2018|
Normothyroid pregnant women
Healthy pregnant women with the TSH serum values within the recommended ranged per trimester of pregnancy.
Patients with a thyroid disease
Patients with a thyroid disease named hypothyroidism or hyperthyroidism.
- TSHβX1 splice variant expression. [ Time Frame: Baseline. ]Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.
- D2 Thr92Ala polymorphism. [ Time Frame: Baseline. ]Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03612908
|Materno-Perinatal Hospital "Mónica Pretelini"|
|Toluca, Mexico, 50130|
|Principal Investigator:||Mendieta Zerón||Hospital Materno-Perinatal "Mónica Pretelini Sáenz".|