Cortical Spreading Depolarization After Severe Traumatic Brain Injury
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Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.
Condition or disease
Traumatic Brain Injury
Diagnostic Test: Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
Determination of foci that give rise to cortical spreading depolarizations [ Time Frame: 2 years ]
Secondary Outcome Measures :
Determine the relationship between cortical spreading depolarization foci of origination and structural pathology demonstrated on brain imaging (CT and MRI). [ Time Frame: 2 years ]
Other Outcome Measures:
Determine the association (if any) between cortical spreading depolarization foci of origination and cortical spreading depolarization frequency with relevant physiological data. [ Time Frame: 2 years ]
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients will be recruited from the population of severe TBI patients clinically judged to require neurosurgical intervention who present through the emergency department or upon direct transfer to the neurosurgery service at Hennepin County Medical Center. The target sample size for this preliminary study is 10 subjects.
Patient recommended to undergo craniectomy or craniotomy for the treatment of acute TBI
Wound determined to be contaminated
Decompression is performed only in the posterior fossa