Syndrome Patterns for Chronic Atrophic Gastritis Malignant Transformation
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|ClinicalTrials.gov Identifier: NCT03314038|
Recruitment Status : Recruiting
First Posted : October 19, 2017
Last Update Posted : October 19, 2017
|Condition or disease|
|TCM Syndrome of Chronic Atrophic Gastritis|
CAG is acknowledged as the precancerous stage GC. Active treatment of CAG is vital in arresting malignant transformation. Traditional Chinese medicine (TCM) has been widely used in treating CAG and preventing GC in China. To date, few study has been conducted to assess the syndrome features of different stages of CAG malignant transformation combining TCM indicators.
The present study aims to explore TCM syndrome features in different stages of CAG malignant transformation. The proposed study is a registry study based participant survey conducted in 4 hospitals in Beijing, China. After obtaining informed consent, a total of 2000 eligible study patients will berecruited on-site in hospitals.
Comparative analysis of prevalence of presenting TCM features is conducted using frequency analysis and chi-squared tests, and expressed with composition ratios. Exploratory factor analysis,correspondence analysis, association rule analysis, hierarchical clustering analysis, and complex system entropy clustering analysis will be performed respectively for validating features of syndrome in different stages of CAG malignant transformation.
Previous reports on TCM syndrome features for CAG exist, but no studies have been undertaken base on large-sampled study design and detailed analysis in different stages of CAG malignant transformation respectively.
The outcome of our study has the potential to clerify core TCM pathogenesis of CAG, facilitate early intervention, and promote optimization of treatment strategies of CAG malignant transformation by TCM.
|Study Type :||Observational|
|Estimated Enrollment :||2000 participants|
|Official Title:||Validating Features of Traditional Chinese Syndrome Patterns for Chronic Atrophic Gastritis Malignant Transformation: A Cross-sectional Study|
|Actual Study Start Date :||January 1, 2014|
|Estimated Primary Completion Date :||December 31, 2018|
|Estimated Study Completion Date :||December 31, 2018|
- TCM syndrome [ Time Frame: one time at involvement (1 day) ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03314038
|Contact: Yin Zhang, MDemail@example.com|
|Contact: Xia Ding, MDfirstname.lastname@example.org|
|Beijing University of Chinese Medicine||Recruiting|
|Beijing, Beijing, China, 100029|
|Contact: Xia Ding, MD email@example.com|
|Principal Investigator:||Xia Ding, MD||Beijing University of Chinese Medicine|