Adipose Tissue Content of Fatty Acids Present in Dairy Fat and Risk of Stroke. The Danish Diet, Cancer and Health Cohort
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|ClinicalTrials.gov Identifier: NCT03220568|
Recruitment Status : Completed
First Posted : July 18, 2017
Last Update Posted : July 18, 2017
Background: Although low-fat dairy products are an integral part of a diet recommended for stroke prevention, the role of dairy fat in relation to the risk of stroke is not yet clear.
Objective: Therefore the association of adipose tissue content of fatty acids, for which dairy products are a major source (12:0, 14:0, 14:1 cis-9, 15:0, 17:0, 18:1 trans-11 and 18:2 cis-9, trans-11), with incident total stroke and stroke subtypes will be investigated.
Design: The study is a case-cohort study nested within the Danish Diet, Cancer and Health cohort, including all incident stroke cases and a random sample of the total cohort.The fatty acid composition of adipose tissue biopsies was determined by gas chromatography and the content of specific fatty acids was expressed as percentage of total fatty acids. Stroke cases were identified in the Danish National Patient Registry and the diagnoses were individually verified. Cox proportional hazard regression will be used to estimate the association between fatty acids and stroke.
|Condition or disease||Intervention/treatment|
|Stroke||Other: Fatty acids present in adipose tissue samples|
|Study Type :||Observational|
|Actual Enrollment :||57053 participants|
|Official Title:||Adipose Tissue Content of Fatty Acids Present in Dairy Fat and Risk of Stroke. The Danish Diet, Cancer and Health Cohort|
|Actual Study Start Date :||November 24, 1993|
|Actual Primary Completion Date :||November 30, 2009|
|Actual Study Completion Date :||November 30, 2009|
- Stroke, including validated subtypes [ Time Frame: From baseline until 30 November 2009 ]
Biospecimen Retention: Samples With DNA