Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
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|ClinicalTrials.gov Identifier: NCT03157466|
Recruitment Status : Completed
First Posted : May 17, 2017
Last Update Posted : August 29, 2018
Although it is now recognized that a variety of respiratory abnormalities, such as diaphragmatic dysfunction, can be present in primary hypothyroidism and reverse with adequate hormone treatment, the role of thyroid hormone replacement therapy on respiratory system in patients with the nonthyroidal illness syndrome (NTIS) remains to be clarified. The NTIS has been found to be an independent risk factor for prolonged (> 13 days) mechanical ventilation. It is unclear, however, whether the NTIS is only a biochemical prognostic marker or it actually contributes to the development and progression of respiratory failure.
The aim of this study will be to assess respiratory muscle function after thyroid hormone substitution therapy in mechanically ventilated patients with the NTIS.
|Condition or disease|
|Thyroid Diseases Respiratory Failure|
|Study Type :||Observational|
|Actual Enrollment :||15 participants|
|Official Title:||Diaphragmatic Efficiency After Thyroid Hormone Replacement Therapy in Ventilated Patients With the Nonthyroidal Illness Syndrome: a Physiological Study|
|Actual Study Start Date :||October 1, 2017|
|Actual Primary Completion Date :||May 1, 2018|
|Actual Study Completion Date :||May 1, 2018|
- Change from baseline neuromechanical efficiency (obtained immediately before starting thyroid hormone therapy) at 3, 6, and 24 hours [ Time Frame: 24 hours (study points at 3, 6, and 24 hours) ]
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03157466
|Fondazione Policlinico Universitario Agostino Gemelli|