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Assessing Dementia Risk in the Community: The Dementia Population Risk Tool (DemPoRT)

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ClinicalTrials.gov Identifier: NCT03155815
Recruitment Status : Completed
First Posted : May 16, 2017
Last Update Posted : February 17, 2020
Sponsor:
Collaborators:
Canadian Institutes of Health Research (CIHR)
Institute for Clinical Evaluative Sciences
Information provided by (Responsible Party):
Ottawa Hospital Research Institute

Brief Summary:
The purpose of this study is to develop and validate the Dementia Population Risk Tool (DemPoRT) algorithm to predict dementia incidence in the population setting.

Condition or disease
Dementia

Detailed Description:

The burden of disease from dementia is a growing global concern as incidence increases exponentially with age and average life expectancy has been increasing around the world. Planning for an aging population requires reliable projections of future dementia prevalence and resource requirements, however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modeling techniques.

The derivation cohort will consist of elderly Ontario respondents of Canadian Community Health Survey (CCHS) (2001, 2003, 2005, 2007; approximately 19 000 males and 25 000 females). Pre-specified predictors include sociodemographic, general health, behavioral, functional and health condition variables. Incident dementia will be identified through individual linkage of survey respondents to population-level administrative health care databases. Using time of first dementia capture as the primary outcome and death as a competing risk, sex-specific proportional hazards regression models will be estimated. The 2008/2009 CCHS survey be used for validation (approximately 4 600 males and 6 300 females). Overall calibration and discrimination will be assessed as well as calibration within predefined subgroups of importance to clinicians and policy makers.

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Study Type : Observational
Actual Enrollment : 75460 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Dementia Population Risk Tool (DemPoRT): A Predictive Algorithm for Assessing Dementia Risk in the Community Setting
Actual Study Start Date : September 2000
Actual Primary Completion Date : March 2014
Actual Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dementia

Group/Cohort
Derivation Cohort
Eligible respondents to the combined 2001, 2003, 2005 and 2007 Canadian Community Health Surveys, conducted by Statistics Canada.
Validation Cohort
Eligible respondents to the 2008/2009 Canadian Community Health Survey.



Primary Outcome Measures :
  1. Dementia capture in administrative data [ Time Frame: Up to 13 years ]
    Identification of incident dementia in administrative data using a validated case ascertainment definition, supplemented by dementia codes captured on home care and long-term care assessments



Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The derivation cohort will be eligible respondents to the combined 2001, 2003, 2005 and 2007 Canadian Community Health Surveys, conducted by Statistics Canada. The validation cohort will consist of respondents to the 2008/2009 survey.
Criteria

Inclusion Criteria:

  • Respondents to the Canadian Community Health Surveys

Exclusion Criteria:

  • Less than 55 years of age at survey administration
  • Prior history of dementia
  • Not eligible for Ontario's universal health insurance program

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03155815


Sponsors and Collaborators
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)
Institute for Clinical Evaluative Sciences
Investigators
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Principal Investigator: Peter Tanuseputro Ottawa Hospital Research Institute
Publications:
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Responsible Party: Ottawa Hospital Research Institute
ClinicalTrials.gov Identifier: NCT03155815    
Other Study ID Numbers: CIHR FRN 142237
First Posted: May 16, 2017    Key Record Dates
Last Update Posted: February 17, 2020
Last Verified: February 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders