Reconstitution of a Human Immune System in a Patient Derived Xenograft (PDX) Model of Genitourinary (GU) Cancers (Immune PDX)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03134027|
Recruitment Status : Recruiting
First Posted : April 28, 2017
Last Update Posted : May 30, 2018
|Condition or disease||Intervention/treatment|
|Genito Urinary Cancer Bladder Cancer Kidney Cancer Prostate Cancer||Procedure: Bone marrow biopsy|
|Study Type :||Observational|
|Estimated Enrollment :||5 participants|
|Official Title:||Reconstitution of a Human Immune System in a Patient Derived Xenograft (PDX) Model of Genitourinary (GU) Cancers|
|Actual Study Start Date :||October 19, 2017|
|Estimated Primary Completion Date :||November 2018|
|Estimated Study Completion Date :||November 2018|
Subjects from which PDXs have been generated.
Subjects will be identified from which PDXs have been generated from an already approved IRB protocol.
Procedure: Bone marrow biopsy
Subjects will undergo a bone marrow biopsy to obtain aspirate for stem cell collection.
- Reconstitution of a matched human immune system in patient derived xenografts (PDXs) [ Time Frame: approximately 4 months ]Number of samples yielding a matched human immune system in immunodeficient mice resulting in a PDX with a humanized immune system.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03134027
|Contact: Julia Rasmussen, MS, RN, BSNemail@example.com|
|United States, North Carolina|
|Duke University Medical Center||Recruiting|
|Durham, North Carolina, United States, 27710|
|Contact: Julia Rasmussen, MS, RN, BSN 919-681-1030 firstname.lastname@example.org|
|Principal Investigator:||Shiaowen David Hsu, MD, PhD||Duke Cancer Institute|