Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke (CUSCAS)
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|ClinicalTrials.gov Identifier: NCT03115242|
Recruitment Status : Completed
First Posted : April 14, 2017
Last Update Posted : March 15, 2018
|Condition or disease||Intervention/treatment||Phase|
|Cerebral Infarction||Other: Contrast injection Sonovue®||Not Applicable|
The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes.
The secondary objectives are:
- to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound.
- to explore of the plaque contrast enhancement at 6 months (new injection).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||35 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke|
|Actual Study Start Date :||August 2015|
|Actual Primary Completion Date :||August 2017|
|Actual Study Completion Date :||August 2017|
Experimental: Acute ischemic carotid stroke
Patients hospitalized in the neurovascular intensive care unit for an acute ischemic stroke with a carotid plaque responding to inclusion criteria.
These patients receive a contrast injection Sonovue® will be performed during the neck vessels doppler ultrasound.
Other: Contrast injection Sonovue®
In addition to standardized assessment routine care, a contrast injection will be performed during the neck vessels doppler ultrasound.
- Contrast enhancement of carotid plaque prevalence in ultrasound doppler [ Time Frame: Day 1 ]
- Patient's demographics data [ Time Frame: Day 1 ]
- Patient's sonographic and MRI characteristics. [ Time Frame: Day1 ]confirmation of the recent character of stroke on the DWI, search for stroke sequelae and white matter disease on the FLAIR, search of the thrombus on the T2*, search occluded artery on the 3DTOF
- describe the aspect of the carotid plaque on CT angiography. [ Time Frame: between 1 to 5 days ]NASCET stenosis and the aspect (smooth, irregular, ulcerated)
- Persistence , decrease or loss of contrast enhancement in ultrasound doppler. [ Time Frame: Month 6 ]
- Cerebral infarction recurrence [ Time Frame: Month 6 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03115242
|Centre Hospitalier de Versailles|
|Le Chesnay, France, 78150|
|Principal Investigator:||Jennifer YEUNG, Neurologist||Versailles Hospital|
|Principal Investigator:||Jean-Michel BAUD, Angiologist||Versailles Hospital|
|OverallOfficial:||Aurélien MAURIZOT, Angiologist||Versailles Hospital|
|OverallOfficial:||Simon CHABAY, Angiologist||Versailles Hospital|
|OverallOfficial:||Daniela STANCIU, Neurologist||Versailles Hospital|