Phase 2 Study of Pembrolizumab, DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
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| ClinicalTrials.gov Identifier: NCT03029403 |
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Recruitment Status :
Recruiting
First Posted : January 24, 2017
Last Update Posted : November 30, 2021
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This is a phase 2 study whose purpose is to see whether the combination of of pembrolizumab, DPX-Survivac vaccine and low-dose cyclophosphamide has anti-tumor activity in patients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.
DPX-Survivac is an investigational vaccine. A vaccine is a substance that is often given to stimulate the body's immune system (the structure and processes in the body that protects against harmful substances) to help prevent against certain diseases. DPX-Survivac is a vaccine that may teach the immune system to recognize cancer cells and to kill them.
Pembrolizumab is a drug that is approved for the treatment of a certain type of melanoma (a type of skin cancer) and non-small cell lung cancer. Pembrolizumab blocks the function of a protein called programmed cell death receptor-1 (PD-1). PD-1 works by keeping the immune system from destroying cancer cells. Stopping PD-1 from working may help the immune system to fight cancer cells.
Cyclophosphamide is chemotherapy drug that is approved for the treatment of various cancers alone and in combination with other drugs.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Advanced Cancer Ovarian Cancer Primary Peritoneal Carcinoma Fallopian Tube Cancer | Drug: Pembrolizumab Biological: DPX-Survivac Drug: Cyclophosphamide | Phase 2 |
This study has two phases: a dose escalation phase and a dose expansion phase.
For the dose escalation part, groups of participants will receive one of two dose levels of study drugs to determine the best dose level for further testing.
Once the best dose level is found, additional participant will be enrolled to the dose expansion to further test the safety, tolerability, and efficacy of the study drugs at that dose level in specific types of cancers. All participants will receive pembrolizumab, DPX-Survivac, and low-dose cyclophosphamide.
Participants will be screened for eligibility by standard safety tests and procedures within 28 days of the start of the study drug. Tests and procedures done for research purposes only during this time include archival tumor tissue collection, fresh research biopsy, and blood sample collection for biomarker/genetic/immune research. Participants will also be asked if they agree to an optional fresh research biopsy at disease progression
Eligible participants will receive the following every 21 day cycle:
- Pembrolizumab, intravenously, at 200 mg, on Day 1 of every cycle.
- DPX-Survivac, by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac depending on the assigned dose level.
- Cyclophosphamide, orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
While receiving the study treatment, participants will be asked to visit the study site on Day 1 of Cycles 1-8 for tests and procedures. Tests and procedures done for research purposes only include additional blood sample collection and a second fresh research biopsy for biomarker/genetic/immune research.
Participants who benefit from the study treatment may be able to receive additional treatment if they progress after stopping the study treatment.
When participants are taken off the study treatment permanently, they will be asked to return to the study site for an End of Study Treatment visit about 30 days after stopping the study treatment to have tests and procedures done for safety purposes.
Participants who are taken off the study treatment for any reason other than disease progression will continue to have radiological assessments and blood draws every 12 weeks for the first year and every 24 weeks after year 1 until they start a new anti-cancer treatment, disease progression, or the study ends. Participants will continue to be followed for survival and to review any new anti-cancer therapies every 12 weeks.
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 42 participants |
| Allocation: | Non-Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Treatment |
| Official Title: | A Phase 2 Study of Pembrolizumab (MK-3475), DPX-Survivac Vaccine and Low Dose of Cyclophosphamide Combination in Patients With Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer |
| Actual Study Start Date : | February 12, 2018 |
| Estimated Primary Completion Date : | February 12, 2023 |
| Estimated Study Completion Date : | February 12, 2024 |
| Arm | Intervention/treatment |
|---|---|
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Experimental: Dose Escalation
Patients with epithelial ovarian, fallopian tube or primary peritoneal cancer.
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Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda Biological: DPX-Survivac Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac. Drug: Cyclophosphamide Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox |
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Experimental: Dose Expansion - Cohort A
Patients with platinum-sensitive epithelial ovarian, fallopian tube or primary peritoneal cancer.
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Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda Biological: DPX-Survivac Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac. Drug: Cyclophosphamide Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox |
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Experimental: Dose Expansion - Cohort B
Patients with platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer.
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Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda Biological: DPX-Survivac Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac. Drug: Cyclophosphamide Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox |
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Experimental: Dose Expansion - Cohort C
Patients with recurrent advanced epithelial ovarian, fallopian tube and primary peritoneal patients with uncommon tumor histologies, including clear cell, mucinous and low grade serous or low grade endometrioid ovarian subtypes.
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Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda Biological: DPX-Survivac Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac. Drug: Cyclophosphamide Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox |
- Overall response rate (ORR) [ Time Frame: 5 years ]ORR will be used to evaluate the clinical anti-tumor activity of Pembrolizumab, DPX Survivac and oral cyclophosphamide combination.
- Progression free survival (PFS) rate [ Time Frame: 5 years ]PFS rate from start of study treatment to time of progression or death whichever comes first
- Overall survival (OS) rate [ Time Frame: 5 years ]OS rate from start of study treatment until death for every cause
- Number of side effects [ Time Frame: 5 years ]Adverse events will be analyzed as safety parameters
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
| Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients must have histologically or cytologically confirmed advanced epithelial ovarian, primary peritoneal or fallopian tube carcinomas.
- Patients must have radiologically documented disease progression from their prior line of therapy.
- Patients must have measurable disease based on RECIST 1.1.
- Have received a front line platinum-based regimen (administered via either IV or IP) following primary or interval debulking surgery with documented disease recurrence.
- Have fulfilled the following additional requirements regarding prior treatments depending on the cohort that the patient is to be enrolled in.
- Eastern Cooperative Group (ECOG) performance status <=1.
- Life expectancy greater than 16 weeks.
- Availability of archival tumor tissue samples. Additional samples may be requested if tumor tissue provided is not adequate for quality and/or quantity as assessed by the laboratory.
- Be willing to provide tumor tissue from a newly obtained core or excisional biopsy prior to start treatment and on day 15 of cycle 1.
Exclusion Criteria:
- Patients who are receiving any other investigational agents.
- Diagnosis of immunodeficiency or therapy with systemic steroid or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
- History of autoimmune disease, such as but not restricted to, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematous, ankylosing spondylitis, scleroderma, or multiple sclerosis requiring treatment within the last two years. Patients with vitiligo or diabetes are not excluded.
- Patients with history of thyroiditis within 5 years.
- Patients with known history of active TB (Bacillus Tuberculosis).
- Patients with known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Hypersensitivity to Pembrolizumab, DPX-Survivac immunovaccine, Cyclophosphamide or any of their excipients.
- Patients that have received a live vaccine within 30 days of planned start of study therapy.
- Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2 agent or DPX-Survivac vaccine.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03029403
| Contact: Amit Oza, M.D. | 416-946-2818 | amit.oza@uhn.ca |
| Canada, Ontario | |
| Princess Margaret Cancer Centre | Recruiting |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Contact: Amit Oza, M.D. | |
| Principal Investigator: Amit Oza, M.D. | |
| Principal Investigator: | Amit Oza, M.D. | Princess Margaret Cancer Centre |
| Responsible Party: | University Health Network, Toronto |
| ClinicalTrials.gov Identifier: | NCT03029403 |
| Other Study ID Numbers: |
PESCO |
| First Posted: | January 24, 2017 Key Record Dates |
| Last Update Posted: | November 30, 2021 |
| Last Verified: | November 2021 |
| Individual Participant Data (IPD) Sharing Statement: | |
| Plan to Share IPD: | No |
| Studies a U.S. FDA-regulated Drug Product: | No |
| Studies a U.S. FDA-regulated Device Product: | No |
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Fallopian Tube Neoplasms Neoplasms by Site Neoplasms Adnexal Diseases Genital Diseases, Female Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Urogenital Diseases Genital Neoplasms, Female Urogenital Neoplasms Genital Diseases Fallopian Tube Diseases Cyclophosphamide |
Pembrolizumab Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Antirheumatic Agents Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Myeloablative Agonists Antineoplastic Agents, Immunological Immune Checkpoint Inhibitors |