A Comparison of Cognitive Training Approaches in Psychotic Disorders
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ClinicalTrials.gov Identifier: NCT03024203 |
Recruitment Status :
Completed
First Posted : January 18, 2017
Last Update Posted : November 14, 2018
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Condition or disease | Intervention/treatment | Phase |
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Psychotic Disorders | Behavioral: Cognitive Remediation - Executive Training Behavioral: Cognitive Remediation - Perceptual Training | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 70 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | A Comparison of Cognitive Training Approaches in Psychotic Disorders |
Actual Study Start Date : | August 2016 |
Actual Primary Completion Date : | March 2018 |
Actual Study Completion Date : | March 2018 |

Arm | Intervention/treatment |
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Experimental: Executive Training
Executive Training (ET) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. ET will be delivered in both individual and group settings.
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Behavioral: Cognitive Remediation - Executive Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability. |
Experimental: Perceptual Training
Perceptual Training (PT) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. PT will be delivered in both individual and group settings.
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Behavioral: Cognitive Remediation - Perceptual Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed. |
- Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline [ Time Frame: Post-treatment (within 2 weeks following the end of treatment) ]Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks
- Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline [ Time Frame: Post-treatment (within 2 weeks following the end of treatment) ]The MCCB is the gold standard cognitive assessment for schizophrenia research
- Change in Neurophysiology - EEG from Baseline [ Time Frame: Post-treatment (within 2 weeks following the end of treatment) ]Alpha and Theta band synchronization, p300, mismatch negativity
- Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline [ Time Frame: Post-treatment (within 2 weeks following the end of treatment) ]Performance based measure of real life functional skills using role-play
- Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline [ Time Frame: Follow-Up (3 months after the end of treatment) ]Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks
- Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline [ Time Frame: Follow-Up (3 months after the end of treatment) ]The MCCB is the gold standard cognitive assessment for schizophrenia research
- Change in Neurophysiology - EEG from Baseline [ Time Frame: Follow-Up (3 months after the end of treatment) ]Alpha and Theta band synchronization, p300, mismatch negativity
- Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline [ Time Frame: Follow-Up (3 months after the end of treatment) ]Performance based measure of real life functional skills using role-play

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- psychotic disorder
- No previous cognitive remediation in past 6 months
Exclusion Criteria:
- Brain injury
- Substance abuse
- Neurocognitive disorder
- Developmental Disability

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03024203
Canada, Ontario | |
Queen's University | |
Kingston, Ontario, Canada, K7L 5P6 |
Responsible Party: | Dr. Christopher Bowie, Principal Investigator, Queen's University |
ClinicalTrials.gov Identifier: | NCT03024203 |
Other Study ID Numbers: |
PSYC-173-16 |
First Posted: | January 18, 2017 Key Record Dates |
Last Update Posted: | November 14, 2018 |
Last Verified: | November 2018 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Mental Disorders Psychotic Disorders Schizophrenia Spectrum and Other Psychotic Disorders |