Saracatinib and Alcohol Drinking
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02955186|
Recruitment Status : Completed
First Posted : November 4, 2016
Last Update Posted : July 10, 2019
|Condition or disease||Intervention/treatment||Phase|
|Alcohol Drinking||Drug: Saracatinib Drug: Placebos||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||54 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Fyn Kinase Inhibitors and Alcohol Drinking|
|Actual Study Start Date :||May 9, 2017|
|Actual Primary Completion Date :||April 24, 2019|
|Actual Study Completion Date :||June 7, 2019|
Experimental: 125 mg saracatinib
Participants will take 125 mg of saracatinib daily for 8 days.
Saracatinib 125 mg once per day for 8 days
Other Name: AZD0530
Placebo Comparator: Placebo
Participants will take placebo daily for 8 days.
Placebo once per day for 8 days
- Number of Drinks Consumed on Day 8 [ Time Frame: Day 8 ]Number of drinks consumed on Day 8
- Baseline adjusted Craving (YCS) [ Time Frame: Day 8 ]Craving for alcohol based on Yale Craving Scale, scores ranging from 0-112 mm on a visual analog scale, with higher measurements indicating higher craving. The baseline-adjusted craving is change score from baseline at Day 7.
- Stimulation and Sedation Responses to Alcohol (BAES) [ Time Frame: Day 8 ]Biphasic Alcohol Effects Scale scores will be used to assess stimulation and sedation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02955186
|United States, Connecticut|
|CMHC, Substance Abuse Center|
|New Haven, Connecticut, United States, 06519|