TransplantLines Food and Nutrition Biobank and Cohort Study (TxL-FN) (TxL-FN)
|Transplantation Infection Renal Transplant Donor of Left Kidney|
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration:||20 Years|
|Official Title:||Renal Sensing of the Acidifying Effect of Sulphur-containing Amino Acids: Consequences for the Relation Between Protein Intake and Blood Pressure in Renal Transplant Recipients|
- Graft failure [ Time Frame: 20 years ]Return to dialysis or re-transplantation
- All-cause mortality [ Time Frame: 20 years ]Death
- Cardiovascular mortality [ Time Frame: 20 years ]Cause specific mortality
- Cancer mortality [ Time Frame: 20 years ]Cause specific mortality
- Infectious disease mortality [ Time Frame: 20 years ]Cause specific mortality
- Change in renal function [ Time Frame: 20 years ]Change in renal function over time
- New Onset Diabetes After Transplantation [ Time Frame: 20 years ]New Onset Diabetes
Biospecimen Retention: Samples Without DNA
|Actual Study Start Date:||November 2008|
|Estimated Study Completion Date:||November 2028|
|Primary Completion Date:||May 2011 (Final data collection date for primary outcome measure)|
Renal Transplant Recipients
Renal Transplant Recipients that were more than 1 year post-transplantation
Healthy subjects being evaluated as potential living kidney donors
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, the investigators hypothesize that due to poor homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant recipients are much more susceptible to poor dietary habits and exposure to potentially toxic contaminants than people of the general population, and that this contributes to accelerated function loss of the graft and excess risk of premature mortality, both contributing to poor long-term results.
To investigate one part of this overarching hypothesis, the investigators wrote a project on around the specific topic of the relation between dietary acid load, ammoniagenesis and its potential influence on blood pressure. The investigators used this project to build a biobank and cohort in which they can test additional hypotheses on the relation between diet, contaminants and development of graft failure and the occurrence of mortality.
The investigators also included 300 healthy controls to compare diet, contaminant exposure and biomarkers with the renal transplant recipients.