Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02717559 |
Recruitment Status :
Active, not recruiting
First Posted : March 23, 2016
Last Update Posted : January 10, 2022
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Condition or disease |
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Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases |
The purpose of this study is to identify risk factors for signs and symptoms of osteoarthritis two and ten year post ACL reconstruction from information available at the time of surgery. Hypothesis: Smoking status, older age, higher BMI, increased severity of cartilage injuries, increased meniscal resection, revision surgery, and incidence of additional arthroscopic procedures will result in more symptoms and signs of osteoarthritis at 10-year follow-up.
Primary outcome measures will be the joint space width measured on weight-bearing radiographs, as well as the pain subscale of the Knee Injury and Osteoarthritis Score (KOOS).
Secondary outcome measures will include the knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS).
Study Type : | Observational |
Actual Enrollment : | 197 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up |
Study Start Date : | March 2016 |
Estimated Primary Completion Date : | July 2025 |
Estimated Study Completion Date : | December 2025 |

- Joint space width measured on weight-bearing radiographs [ Time Frame: 10 years after ACL reconstruction surgery ]
- Pain subscale of the Knee Injury and Osteoarthritis Score (KOOS). [ Time Frame: 10 years after ACL reconstruction surgery ]
- Knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS) [ Time Frame: 10 years after ACL reconstruction surgery ]

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Ages Eligible for Study: | 20 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Had primary unilateral ACL reconstruction performed by Dr. Kurt Spindler (Vanderbilt University), Dr. Christopher Kaeding (The Ohio State University), Dr. Rick Parker (Cleveland Clinic), or Dr. Jack Andrish (Cleveland Clinic).
- Participated in the 2 yr onsite visit
Exclusion Criteria:
- Non-active or unable to participate for health reasons
- Cannot return to the original site of testing
- Unable to be consented
- Insufficient initial documentation
- Cannot be contacted by phone
- History of total knee arthroplasty on either knee
- History of revision ACLR on the knee for which the patient was originally enrolled
- History of intra-articular knee infection

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02717559
Principal Investigator: | Kurt P Spindler, MD | Vanderbilt University / The Cleveland Clinic Foundation |
Responsible Party: | Kurt P. Spindler, Adjoint Professor, Vanderbilt University Medical Center |
ClinicalTrials.gov Identifier: | NCT02717559 |
Other Study ID Numbers: |
160049 |
First Posted: | March 23, 2016 Key Record Dates |
Last Update Posted: | January 10, 2022 |
Last Verified: | January 2022 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Anterior cruciate ligament / injuries Anterior cruciate ligament / surgery knee injuries / surgery |
outcomes research prospective studies osteoarthritis |
Osteoarthritis Rheumatic Diseases Joint Diseases Musculoskeletal Diseases |
Collagen Diseases Arthritis Connective Tissue Diseases |