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Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02688738
Recruitment Status : Unknown
Verified February 2016 by Rothman Institute Orthopaedics.
Recruitment status was:  Enrolling by invitation
First Posted : February 23, 2016
Last Update Posted : February 23, 2016
Information provided by (Responsible Party):
Rothman Institute Orthopaedics

Brief Summary:
The purpose of this study is to evaluate the ability of oral doxycycline to decrease the colonization of Propionibacterium acnes in the dermis of the shoulder.

Condition or disease Intervention/treatment Phase
Propionibacterium Drug: Doxycycline Not Applicable

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Study Type : Interventional  (Clinical Trial)
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
Official Title: Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?
Study Start Date : March 2015
Estimated Primary Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Acne

Arm Intervention/treatment
No Intervention: Control
Standard of care
Active Comparator: Treatment
Oral doxycycline
Drug: Doxycycline

Primary Outcome Measures :
  1. Quantification of P acnes grown from anaerobic or aerobic culture [ Time Frame: within 14 days of surgery ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult

Inclusion Criteria:

-All male patients (>18 years of age) undergoing shoulder arthroscopy

Exclusion Criteria:

  • Female patients
  • patients with active acne
  • patients who have taken antibiotics in the past month
  • doxycycline allergy
  • benzoyl peroxide allergy
  • clindamycin allergy
  • patients with psoriatic/eczematous or other lesions on the shoulder girdle.
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Responsible Party: Rothman Institute Orthopaedics Identifier: NCT02688738    
Other Study ID Numbers: 2016SNam
First Posted: February 23, 2016    Key Record Dates
Last Update Posted: February 23, 2016
Last Verified: February 2016
Additional relevant MeSH terms:
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Anti-Bacterial Agents
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents