We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment (CANVAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02677415
Recruitment Status : Recruiting
First Posted : February 9, 2016
Last Update Posted : March 14, 2017
Information provided by (Responsible Party):
Yuming Peng, Beijing Tiantan Hospital

Brief Summary:
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.

Condition or disease Intervention/treatment
Acute Stroke Other: Intravenous anesthetics Other: local anesthesia Other: Controlled ventilation Other: Spontaneous breathing

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 640 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Impact of General vs Local Anesthesia on Neurological Function in Patients With Acute Ischemic Stroke Undergoing Endovascular Treatment
Actual Study Start Date : September 2016
Estimated Primary Completion Date : December 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anesthesia
U.S. FDA Resources

Arm Intervention/treatment
Local anesthesia
local anesthesia and spontaneous breathing will be maintained.
Other: local anesthesia Other: Spontaneous breathing
General anesthesia
Intravenous anesthetics and controlled ventilation will be used .
Other: Intravenous anesthetics Other: Controlled ventilation

Primary Outcome Measures :
  1. modified Rankin score [ Time Frame: post-procedural 30 days ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 6 hours.

Exclusion Criteria:

  • Radiological ambiguity concerning infarction and vessel occlusion.
  • Additional intracerebral hemorrhage.
  • Posterior circulation infraction.
  • Coma on admission (Glasgow coma score less than 8).
  • NIHSS less than 10 or more than 30.
  • Severe agitation or seizures on admission.
  • Obvious loss of airway protective reflexes and/or vomiting on admission.
  • Being intubated before treatment on admission.
  • Known allergy to anesthetic or analgesic.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02677415

Contact: Ruquan Han, M.D., Ph.D. 8610-67096660 ruquan.han@gmail.com

Beijing TianTan Hospital Recruiting
Beijing, China, 100050
Contact: Ruquan Han, M.D., Ph.D    8610-67096660    ruquan.han@gmail.com   
Sponsors and Collaborators
Beijing Tiantan Hospital
Principal Investigator: Ruquan Han, M.D., Ph.D. Department of Anesthesiology, Beijing Tiantan Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Yuming Peng, M.D., Ph.D., Beijing Tiantan Hospital
ClinicalTrials.gov Identifier: NCT02677415     History of Changes
Other Study ID Numbers: QML20150508
First Posted: February 9, 2016    Key Record Dates
Last Update Posted: March 14, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Keywords provided by Yuming Peng, Beijing Tiantan Hospital:
Ischemic Stroke
Endovascular Procedures

Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Anesthetics, Intravenous
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, General