Preoperative HIIT in Elderly Cancer Patients (eHIITCa)
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|ClinicalTrials.gov Identifier: NCT02671617|
Recruitment Status : Completed
First Posted : February 2, 2016
Last Update Posted : September 14, 2018
This randomized control trial will determine the effect of short term high intensity interval training (HIIT) on physical fitness, in an elderly patient group with active cancer, prior to surgical resection.
Half of the recruited patients will act as a control group and the other half will undergo a HIIT protocol.
|Condition or disease||Intervention/treatment||Phase|
|Cancer||Other: High intensity interval training (HIIT)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||A Randomised Control Trial to Assess Efficacy of Preoperative High Intensity Interval Training in Elderly Patients Scheduled for Oncological Abdominal Surgery|
|Study Start Date :||August 2016|
|Actual Primary Completion Date :||July 2018|
|Actual Study Completion Date :||August 2018|
No Intervention: Control
Control: This group of patients will receive 'current best practice' as per UK NHS recommendations for their specific cancer management prior to surgery.
Experimental: High intensity interval training
Exercise: Participants in this group will attend 3-4 times per week to complete HIIT training during the period from diagnosis to surgery.
High intensity interval training (HIIT)
Other: High intensity interval training (HIIT)
Preoperative HIIT protocol.
- VO2AT (VO2 at anaerobic threshold) [ Time Frame: Baseline and 4 weeks ]Change in anaerobic threshold seen during maximal exercise test (pre and post intervention).
- VO2peak [ Time Frame: Baseline and 4 weeks ]Change in peak volume of oxygen consumption during maximal exercise test (pre and post intervention).
- Subjective acceptability of HIIT preoperatively (via questionnaire) [ Time Frame: After 4 weeks of HIIT. ]Assessment of whether our HIIT protocol is acceptable to patients in this age group.
- Muscle protein synthesis rate changes with HIIT. [ Time Frame: Baseline and 4 weeks. ]Assessment of the effect HIIT has on rate of muscle protein synthesis in this group.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02671617
|Royal Derby Hospital|
|Derby, Derbyshire, United Kingdom, DE22 3NE|
|Principal Investigator:||John Williams, MBChB FRCA PhD||Nottingham University|