Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging
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|ClinicalTrials.gov Identifier: NCT02608944|
Recruitment Status : Withdrawn (MRI perfusion techniques development took longer than expected.)
First Posted : November 20, 2015
Last Update Posted : September 14, 2020
|Condition or disease||Intervention/treatment||Phase|
|MRI Scans||Drug: Adenosine Drug: Regadenoson Drug: O-15 labeled radioactive water Device: MRI Device: PET Imaging||Not Applicable|
This project aims to determine the validity of quantitative MRI perfusion methods by comparison with quantitative PET imaging. First pass dynamic contrast enhanced MRI scans will be performed at rest and during hyperemia caused by either adenosine infusion or regadenoson. After custom reconstruction and post-processing the data will be fit to a compartment model and quantitative perfusion and MPR values obtained.
On another day, the subjects will have quantitative PET imaging with O-15 labeled radioactive water. This will be done at rest and hyperemia caused by either adenosine or regadenoson. A low dose CT scan will be acquired to perform attenuation correction of the PET images. The images will be reconstructed and processed as reported in the literature to provide reference standard perfusion and MPR values. These values will be compared with those obtained by MRI.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Official Title:||Comparison of New MRI Methods for Quantitative Assessment of Myocardial Perfusion With Quantitative PET Perfusion Imaging|
|Actual Study Start Date :||September 30, 2012|
|Actual Primary Completion Date :||June 12, 2019|
|Actual Study Completion Date :||June 12, 2019|
Experimental: MRI perfusion vs. PET Imaging perfusion
Adenosine Regadenoson O-15 labeled radioactive water MRI PET Imaging
Adenosine: 0.14mg/kg/min for 6 min. IV injection for MRI perfusion
Regadenoson: 0.4mg in 5ml, given as a rapid (10 seconds) IV injection for MRI perfusion.
Other Name: Lexiscan
Drug: O-15 labeled radioactive water
O-15 labeled radioactive water: Up to 50mCi IV injection at rest and again at hyperemia for PET Imaging
Other Name: O-15 water
Pass dynamic contrast enhanced MRI scans will be performed at rest and during hyperemia caused by either adenosine infusion or regadenoson
Device: PET Imaging
Quantitative PET imaging with O-15 labeled radioactive water will be given at a different day.
Other Name: Positron Emission Tomography Imaging
- Myocardial perfusion values from MRI [ Time Frame: The scan will take ~1-2 hours. The MRI will be done within 2 months of the PET scan. ]Myocardial perfusion in segments and coronary territories will be computed in ml/min/g from the dynamic MRI data. The perfusion values will be compared to PET data to determine how similar the values are.
- Myocardial perfusion values from PET [ Time Frame: The scan will take ~1-2 hours. The PET scan will be done within 2 months of the MRI. ]Myocardial perfusion in segments and coronary territories will be computed in ml/min/g from the dynamic PET data. The perfusion values will be compared to MRI data to determine how similar the values are.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02608944
|United States, Utah|
|University of Utah, Radiology Research|
|Salt Lake City, Utah, United States, 84108|
|Principal Investigator:||Edward DiBella, Ph.D.||University of Utah|