We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Conjugated Linoleic Acid in Obese Women (CLA)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02529046
First Posted: August 19, 2015
Last Update Posted: August 19, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Edilson Serpeloni Cyrino, Universidade Estadual de Londrina
  Purpose
In this trial, the investigators analyzed the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women.

Condition Intervention
Lipid Metabolism Disorders Obesity Dietary Supplement: CLA Behavioral: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial

Resource links provided by NLM:


Further study details as provided by Edilson Serpeloni Cyrino, Universidade Estadual de Londrina:

Primary Outcome Measures:
  • Body fat [ Time Frame: 8 weeks ]
    Dual-energy X-ray absorptiometry


Secondary Outcome Measures:
  • Total cholesterol [ Time Frame: 8 weeks ]
    Blood analysis

  • Triglycerides [ Time Frame: 8 weeks ]
    Blood analysis

  • High-density lipoprotein [ Time Frame: 8 weeks ]
    Blood analysis

  • Low-density lipoprotein [ Time Frame: 8 weeks ]
    Estimated by Friedewald formula

  • Trunk fat [ Time Frame: 8 weeks ]
    Dual-energy X-ray absorptiometry

  • Arm fat [ Time Frame: 8 weeks ]
    Dual-energy X-ray absorptiometry

  • Leg fat [ Time Frame: 8 weeks ]
    Dual-energy X-ray absorptiometry


Other Outcome Measures:
  • Body mass [ Time Frame: 8 weeks ]
    Urano, model PS 180

  • Maximum oxygen uptake [ Time Frame: 8 weeks ]
    incremental treadmill test


Enrollment: 28
Study Start Date: March 2007
Study Completion Date: July 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Aerobic exercise associated with CLA
CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%).
Dietary Supplement: CLA
CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%). Aerobic exercise associated with CLA
Placebo Comparator: Aerobic exercise
Placebo group received 4 g/day of olive oil.
Behavioral: Placebo
Placebo group received 4 g/day of olive oil. Aerobic exercise

Detailed Description:
The aim of this investigation was to analyze the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women. The investigators performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or 4 g/d of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (DXA) and biochemical analysis (blood sample) were assessed before and after the intervention period.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Had no signs or symptoms of disease
  • No orthopedic injuries
  • Must be inactive or moderately active (defined as performing any type of physical exercise less than twice a week)
  • Must be non-smokers
  • Must be free from the use of ergogenic aids
  • Had no metabolic disorders or chronic degenerative diseases
  • Not use drug therapy for body mass loss.

Exclusion Criteria:

  • Had frequency to training sessions below 85% of the total sessions
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02529046


Locations
Brazil
Universidade Estadual de Londrina
Londrina, Paraná, Brazil, 86.057-970
Sponsors and Collaborators
Universidade Estadual de Londrina
Investigators
Study Chair: Edilson Cyrino, PhD Universidade Estadual de Londrina
  More Information

Publications:

Responsible Party: Edilson Serpeloni Cyrino, Professor, Universidade Estadual de Londrina
ClinicalTrials.gov Identifier: NCT02529046     History of Changes
Other Study ID Numbers: ESCyrino
First Submitted: August 4, 2015
First Posted: August 19, 2015
Last Update Posted: August 19, 2015
Last Verified: August 2015

Additional relevant MeSH terms:
Metabolic Diseases
Lipid Metabolism Disorders