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Efficacy and Safety of PARPi to Treat Pancreatic Cancer

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ClinicalTrials.gov Identifier: NCT02511223
Recruitment Status : Unknown
Verified March 2017 by Sheba Medical Center.
Recruitment status was:  Recruiting
First Posted : July 29, 2015
Last Update Posted : September 29, 2017
Sponsor:
Information provided by (Responsible Party):
Sheba Medical Center

Brief Summary:

This is an open label, single arm, phase II trial of Olaparib for PDAC patients with BRCAness. All study subjects will receive Olaparib in a dose of 300 mg p.o twice daily. Treatment will continue until progression, intolerable toxicity or as per patient preference.

Primary objective:

To determine the efficacy of Olaparib monotherapy in stage IV pancreatic ductal adenocarcinoma (PDAC)with BRCAness (BRCA-Breast Cancer susceptibility gene).


Condition or disease Intervention/treatment Phase
Pancreatic Cancer Drug: OLAPARIB Phase 2

Detailed Description:

An open label, single arm, phase II trial of Olaparib for PDAC patients with BRCAness (BRCA-Breast Cancer susceptibility gene).

Patients with previously identified Loss of ATM (ATM serine/threonine kinase)by IHC OR- Family history of BRCA-associated cancers: breast, ovarian, pancreatic, gastric or prostate must be present in 2 or more first-degree relatives OR- Patients with previously identified genetic aberrations that are associated with HRD will be eligible [e.g. somatic BRCA mutation, Fanconi Anemia gene or RAD51(eukaryote gene) mutations].

All patients will be retrospectively investigated for HRD(Homologous recombination repair deficiencies) signature using transcriptome profiling and ATM expression and the results correlated with PARPi (Polyadenosine 5'diphosphoribose [poly (ADP ribose)] polymerisation INHIBITOR) response rates.

Eligible patients will receive treatment with Olaparib tablets p.o 300 mg twice daily until progression. Each treatment cycle is described as 28 days long. Patients will have tumor assessments according to RECIST 1.1(Response Evaluation Criteria In Solid Tumors) at baseline. Patients will then be followed for the final analysis of OS.

Eligible patients will be those patients with stage IV pancreas cancer previously treated for metastatic disease. Patients must have received one prior therapy for the treatment of metastatic disease or refused chemotherapy.

Following study entry, patients will attend clinic visits every two weeks for the first 4 weeks of treatment (Days 1 and 15,). Patients will then attend clinic visits every 4 weeks whilst on study treatment.

Patients should continue to receive study treatment until objective radiological disease progression as per RECIST as assessed by the investigator and as long as in the investigator's opinion they are benefiting from treatment and they do not meet any other discontinuation criteria.

Following discontinuation of study treatment, patients should be seen at 30 days post discontinuation for the evaluations outlined in the study schedule. Patients will be contacted in the 7 days following a specified date (data cut-off date) to capture survival status at that point for each survival analysis.

Patients will have tumor assessments according to RECIST at baseline and every 8 weeks (±1week) up to 40 weeks and then every 12 weeks (±1 week) relative to date of enrolment until objective radiological disease progression according to modified RECIST criteria. Ongoing collection of site review tumor assessment is required and must be recorded in the electronic case report form (eCRF).

Any patient who discontinues study treatment for reasons other than objective radiological progression should continue to undergo scheduled objective tumor assessments according to the study schedule,in order to assess objective radiological progression of disease. Failure to do so may result in bias to the study results.


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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 24 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: PHASE II Study - EFFICACY AND SAFETY OF PARPi TO TREAT PANCREATIC CANCER
Actual Study Start Date : July 2016
Estimated Primary Completion Date : September 2017
Estimated Study Completion Date : October 2017

Resource links provided by the National Library of Medicine

Drug Information available for: Olaparib

Arm Intervention/treatment
Experimental: Single Arm
Only one Arm,All patients will receive Olaparib 300 mg (MILIGRAM)bid p.o till disease progression
Drug: OLAPARIB
Olaparib 300 MG twice a day per os given every day until disease progression or toxicity
Other Name: PARPi




Primary Outcome Measures :
  1. Objective Response Rate (ORR) by using RECIST 1.1 [ Time Frame: approximately- 24 months ]

Secondary Outcome Measures :
  1. Overall Survival (OS) [ Time Frame: approximately- 24 months ]
  2. Progression Free Survival (PFS) [ Time Frame: approximately- 24 months ]
  3. Carbohydrate antigen (CA )19-9 response rate [ Time Frame: approximately- 24 months ]
  4. Number of adverse events (AEs) and serious adverse events (SAEs); [ Time Frame: approximately- 24 months ]
  5. Composite measure of dose interruptions, reductions and dose intensity [ Time Frame: approximately- 24 months ]

Other Outcome Measures:
  1. Retrospective analysis of HRD signature by composite measure: ATM expression (IHC) DNA exploratory analysis [ Time Frame: approximately- 24 months ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • • Patients must be male or female ≥18 years of age

    • Patients with histologically or cytologically confirmed metastatic adenocarcinoma of the pancreas.
    • Patients must have tested negative for BRCA 1 or 2 germline deleterious mutation or be ineligible for BRCA testing [as determined by their insurer]
    • Patients with previously identified Loss of ATM by IHC OR
    • Family history of BRCA-associated cancers: breast, ovarian, pancreatic, gastric or prostate must be present in 2 or more first-degree relatives OR
    • Patients with previously identified genetic aberrations that are associated with HRD will be eligible [e.g. somatic BRCA mutation, Fanconi Anemia gene or RAD51 mutations].
    • Patients must have received at least one prior therapy for metastatic disease or have refused chemotherapy to be eligible
    • Patients with measurable disease and/or non-measurable or no evidence of disease assessed at baseline by CT (or MRI where CT is contraindicated) will be entered in this study. RECIST 1.1 has been modified to allow the assessment of progression due to new lesions in patients with no evidence of disease at baseline
    • ECOG (Eastern Cooperative Oncology Group: A performance status using scales and criteria to assess how a patient's disease is progressing)Performance Status 0-1 (Karnofsky >70).
    • Patients must have adequate organ and marrow function as defined below:
  • Leukocytes >3,000 cells/mm3
  • Absolute neutrophil count >1,500 cells/mm3
  • Platelets >100,000 cells/mm3
  • Hemoglobin >9 g/dl (no blood transfusions within 4 weeks prior to enrolment)
  • Total bilirubin <1.5 X institutional upper limit of normal (IULN)
  • AST aspartate aminotransferase (SGOT)/ALT Alanine transaminase(SGPT) <2.5 X IULN without liver metastasis <5 X IULN for patients with liver metastasis
  • Creatinine within normal institutional limits OR
  • Creatinine clearance >60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

    • INR(international normalized ratio ) <1.5
    • Women of childbearing potential (defined as not post-menopausal for 12 months or no previous surgical sterilization) and fertile men must agree to use adequate contraception for the duration of study participation. Male subjects must agree to refrain from sperm donation during the study and for 30 days after the last dose of study drugs.
    • Ability to understand and the willingness to sign a written informed consent document. Signed informed consent form must be obtained prior to initiation of study evaluations and/or activities.

Exclusion Criteria:

  • Uncontrolled intercurrent illness including symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia and myocardial infarction (MI) within 3 months of initiation of therapy.

    • Pregnancy or lactation
    • Patient has active and uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy
    • Patient has undergone major surgical resection within 4 weeks prior to enrollment.
    • Patient received radiotherapy, surgery, chemotherapy, or an investigational therapy within 2 weeks prior to study entry.
    • Patient has serious medical risk factors involving any of the major organ systems such that the investigator considers it unsafe for the patient to receive an experimental research drug
    • Serious psychiatric or medical conditions that could interfere with treatment
    • History of prior malignancy unless the malignancy has been treated with no evidence of active disease and more than 2 years from initial diagnosis
    • Major bleeding in the last 4 weeks prior to study entry

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02511223


Contacts
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Contact: Talia Golan, MD +972 3 5307099 Talia.Golan@sheba.health.gov.il
Contact: Aliza Ackerstein, Msc 00972-3-5308402 Aliza.Ackerstein@sheba.health.gov.il

Locations
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Israel
Sheba Medical Centre Recruiting
Ramat Gan, Israel
Contact: Talia Golan, MD    +972 3 5307099    Talia.Golan@sheba.health.gov.il   
Contact: aliza ackerstein, Msc    97235307036    aliza.ackerstein@sheba.health.gov.il   
Sponsors and Collaborators
Sheba Medical Center
Investigators
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Principal Investigator: Talia Golan, MD Sheba medical centre Israel

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Responsible Party: Sheba Medical Center
ClinicalTrials.gov Identifier: NCT02511223     History of Changes
Other Study ID Numbers: SHEBA-14-2358-TG-CTIL
First Posted: July 29, 2015    Key Record Dates
Last Update Posted: September 29, 2017
Last Verified: March 2017
Additional relevant MeSH terms:
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Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Endocrine Gland Neoplasms
Digestive System Diseases
Pancreatic Diseases
Endocrine System Diseases
Olaparib
Poly(ADP-ribose) Polymerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents