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Protein Requirements in Endurance-trained Athlete (EP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02478801
Recruitment Status : Completed
First Posted : June 23, 2015
Last Update Posted : June 16, 2016
Ajinomoto Co., Inc.
Information provided by (Responsible Party):
Daniel Moore, University of Toronto

Brief Summary:

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.

Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Condition or disease Intervention/treatment Phase
Increased Metabolic Requirement Healthy Dietary Supplement: amino acids intake Early Phase 1

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 9 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Evaluation of Protein Requirements in Male Endurance Athletes
Study Start Date : March 2015
Actual Primary Completion Date : January 2016
Actual Study Completion Date : May 2016

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Endurance trained
subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.
Dietary Supplement: amino acids intake
amino acids intakes will be varied at 0.2-2.8 g/kg/day

Primary Outcome Measures :
  1. 13CO2 (carbon dioxide) excretion (μmol/kg/h) [ Time Frame: 4 hours / study day ]

Secondary Outcome Measures :
  1. [13C]phenylalanine oxidation (μmol/kg/h) [ Time Frame: 4 hours/study day ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy, male, endurance-trained participants who regularly more than 40 km/week
  • Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion Criteria:

  • Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
  • Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
  • Regular tobacco use
  • Illicit drug use
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Daniel Moore, Assistant Professor, University of Toronto Identifier: NCT02478801    
Other Study ID Numbers: IAAO-E
First Posted: June 23, 2015    Key Record Dates
Last Update Posted: June 16, 2016
Last Verified: June 2016