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Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

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ClinicalTrials.gov Identifier: NCT02459470
Recruitment Status : Completed
First Posted : June 2, 2015
Last Update Posted : June 2, 2015
Sponsor:
Information provided by (Responsible Party):
Samsung Medical Center

Brief Summary:
The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

Condition or disease Intervention/treatment Phase
Kidney Transplantation Procedure: Fluid loading Not Applicable

Detailed Description:
Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 42 participants
Intervention Model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Utility of Stroke Volume Variation and Pulse Pressure Variation for Predicting Fluid Responsiveness in Chronic Renal Failure Patients Undergoing Kidney Transplantation
Study Start Date : December 2012
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: SVV and PPV

SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences)

PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System)

Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Procedure: Fluid loading
fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients
Other Name: HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland




Primary Outcome Measures :
  1. stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system [ Time Frame: within 5 minutes after fluid expansion ]
    predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness

  2. pulse pressure variation from philips Intelivue MP70 monitor [ Time Frame: within 5 minutes after fluid expansion ]
    predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness



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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

- chronic renal failure patients undergoing renal transplantation

Exclusion Criteria:

  • patients with cardiac arrhythmia
  • patients with reduced left ventricular function (EF < 40%)
  • patients with valvular heart disease
  • patients intracardiac shunt
  • patients with pulmonary hypertension
  • patients with extensive peripheral vascular disease
  • patients with preoperative use of vasopressors or inotropics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02459470


Locations
Korea, Republic of
Samsung Seoul Hospital, Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Gaab Soo Kim, M.D, Ph.D. Department of Anesthesiology and Pain medicie, Samsung Medical Center

Responsible Party: Samsung Medical Center
ClinicalTrials.gov Identifier: NCT02459470     History of Changes
Other Study ID Numbers: 2013-03-080
2013-03-180 ( Other Identifier: Samsung Medical Center )
First Posted: June 2, 2015    Key Record Dates
Last Update Posted: June 2, 2015
Last Verified: December 2012

Keywords provided by Samsung Medical Center:
Fluid Responsiveness
Pulse Pressure Variation
Stroke Volume Variation