Neural and Psychological Mechanisms of Pain Perception
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|ClinicalTrials.gov Identifier: NCT02446262|
Recruitment Status : Recruiting
First Posted : May 18, 2015
Last Update Posted : August 9, 2018
- Painful stimuli cause changes in a network of brain regions called the Pain Matrix. But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain and receive treatments that can modify pain. They want to see if these factors influence decisions about pain and how the body responds to it. They also want to compare pain with responses like taste and vision.
- To better understand how pain and emotions are processed and influenced by psychological factors.
- Healthy volunteers ages 18 50.
- This study requires 1 to 2 clinic visits that last 1 to 3 hours.
- Participants will be screened with medical history and physical exam.
- Some participants will have one or more magnetic resonance imaging (MRI) scans of their brain. For MRI, participants will lie on a table that slides in and out of a cylinder. The scanner makes loud knocking noises. They will get earplugs.
- Participants heart activity will be recorded with electrocardiogram. Their pulse, sweating, and breathing will be monitored.
- Some participants will take a taste test. Others may perform simple tasks. Others may receive pain in their arm, leg, or hand. The pain will come from heat or electric shocks. Others may judge pain using a topical pain-relieving cream. Some of these tests may be given during MRI.
- Participants will fill out questionnaires.
- The study will last 3 years.
|Condition or disease|
|Affective Neuroscience Pain Visual Analogue Pain Scale Placebo Functional Magnetic Resonance Imaging (fMRI)|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||Neural and Psychological Mechanisms of Pain Perception|
|Study Start Date :||May 14, 2015|
|Estimated Primary Completion Date :||December 3, 2018|
|Estimated Study Completion Date :||December 3, 2018|
- Pain perception (pain ratings) [ Time Frame: 2 years ]
- State-trait anxiety index, Fear of Pain questionnaire, Intolerance of Uncertainty questionnaire, McGill Pain Questionnaire) [ Time Frame: 2 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02446262
|Contact: Adebisi O Ayodele, C.R.N.P.||(301) firstname.lastname@example.org|
|Contact: Lauren Y Atlas, Ph.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Lauren Y Atlas, Ph.D.||National Center for Complementary and Integrative Health (NCCIH)|