COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Rhinosinusites Chroniques

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02407275
Recruitment Status : Unknown
Verified March 2015 by Institut Hospitalo-Universitaire Méditerranée Infection.
Recruitment status was:  Recruiting
First Posted : April 2, 2015
Last Update Posted : April 2, 2015
University Hospital, Marseille
Information provided by (Responsible Party):
Institut Hospitalo-Universitaire Méditerranée Infection

Brief Summary:

To analyse and describe sinus microbiota, during hard to treat (or refractory) rhinosinusitis, using culturomic and metagenomic methods (i.e. to culture on many different medium of culture to grow hard to cultivate bacteria + to sequence and analyse all DNA contained in samples).

Samples are middle meatus swabs or pus aspiration, done during usually patient following.

Condition or disease Intervention/treatment Phase
Sinusitis Chronic Disease Refractory Other: Biological sample Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Study Start Date : February 2015
Estimated Primary Completion Date : September 2015

Arm Intervention/treatment
biological sample
Genomic & culturomic analyses
Other: Biological sample

Primary Outcome Measures :
  1. Sinusian microbiota description [ Time Frame: 6 months ]
    species, number and type of isolated microbes

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • >18 year old
  • chronic refractory rhinosinusitis
  • to require middle meatus swab or other sinus sample
  • absence of opposition

Exclusion Criteria:

  • <18 year old
  • pregnant women
  • breastfeeding
  • under trusteeship
  • under guardianship

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02407275

Layout table for location contacts
Contact: Erwan Le Dault 0033699662257
Contact: Pierre-Edouard Fournier, Professor

Layout table for location information
Service ORL et de Chirurgie Cervico - Faciale/ AP-HM Recruiting
Marseille, France
Contact: Pierre-Edouard Fournier    04 91 38 55 17   
Sub-Investigator: Pierre-Edouard Fournier         
Principal Investigator: Justin Michel         
Sub-Investigator: Patrick Dessi         
Sub-Investigator: Martin Penicaud         
Sub-Investigator: Michael Achache         
Sub-Investigator: Arnaud Paganelli         
Sponsors and Collaborators
Institut Hospitalo-Universitaire Méditerranée Infection
University Hospital, Marseille
Layout table for investigator information
Study Chair: Pierre-Edouard Fournier, Professor IHU Méditerranée Infection
Layout table for additonal information
Responsible Party: Institut Hospitalo-Universitaire Méditerranée Infection Identifier: NCT02407275    
Other Study ID Numbers: IHU Méditerranée Infections
First Posted: April 2, 2015    Key Record Dates
Last Update Posted: April 2, 2015
Last Verified: March 2015
Additional relevant MeSH terms:
Layout table for MeSH terms
Chronic Disease
Disease Attributes
Pathologic Processes
Paranasal Sinus Diseases
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases