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Factors Associated With Maintenance of Antibody Responses to Influenza Vaccine in Older, Community-Dwelling Adults

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ClinicalTrials.gov Identifier: NCT02401893
Recruitment Status : Completed
First Posted : March 30, 2015
Last Update Posted : March 30, 2015
Sponsor:
Collaborators:
Centers for Disease Control and Prevention
Marshfield Clinic Research Foundation
Information provided by (Responsible Party):
Keipp Talbot, Vanderbilt University

Brief Summary:
Little is known about factors associated with maintenance of hemagglutinin inhibition (HAI) antibodies after influenza vaccination in older adults so the investigators enrolled adults ≥50 years.

Condition or disease Intervention/treatment
Aging Biological: Influenza Vaccine

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Study Type : Observational
Actual Enrollment : 510 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Factors Associated With Maintenance of Antibody Responses to Influenza Vaccine in Older, Community-Dwelling Adults
Study Start Date : September 2009
Actual Primary Completion Date : July 2010
Actual Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Flu Flu Shot


Intervention Details:
  • Biological: Influenza Vaccine
    Everyone immunized as recommended by current guidelines


Primary Outcome Measures :
  1. Maintenance of Immune Response using Hemagglutinin inhibition titers [ Time Frame: 1 year ]

Biospecimen Retention:   Samples With DNA
serum samples were collected


Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects were enrolled at Vanderbilt University Medical Center and Marshfield Clinic Research Foundation during September and October 2009. Subjects were eligible for recruitment if they were ≥50 years of age and had no previous allergy or reaction to influenza vaccination.
Criteria

Inclusion Criteria:

  • Age >=50 years

Exclusion Criteria:

  • Prior vaccine allergy or history of guillain barre
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Keipp Talbot, Assistant Professor, Vanderbilt University
ClinicalTrials.gov Identifier: NCT02401893    
Other Study ID Numbers: Serum 2009
First Posted: March 30, 2015    Key Record Dates
Last Update Posted: March 30, 2015
Last Verified: March 2015
Keywords provided by Keipp Talbot, Vanderbilt University:
aging
influenza vaccine
immune responses
Additional relevant MeSH terms:
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Influenza, Human
Orthomyxoviridae Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Infections
Respiratory Tract Diseases