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Assessing the PK of Met DR, Met IR, and Met XR in Healthy Subjects

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ClinicalTrials.gov Identifier: NCT02291510
Recruitment Status : Completed
First Posted : November 14, 2014
Results First Posted : September 21, 2015
Last Update Posted : December 2, 2016
Sponsor:
Information provided by (Responsible Party):
Elcelyx Therapeutics, Inc.

Brief Summary:
This study compared the pharmacokinetics (PK) and assessed the safety of delayed-release metformin (Met DR, EFB0027) at two dosage levels, immediate-release metformin (Met IR, ETB0015), and extended-release metformin (Met XR, ETB0014) in healthy subjects.

Condition or disease Intervention/treatment Phase
Healthy Subjects Drug: Met DR Drug: Met XR Drug: Met IR Phase 1

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: A Randomized, Crossover Study Assessing the Pharmacokinetics of EFB0027 Versus ETB0015 and ETB0014 in Healthy Subjects
Study Start Date : October 2012
Actual Primary Completion Date : December 2012
Actual Study Completion Date : December 2012

Arm Intervention/treatment
Experimental: 500 mg Met DR BID
Two doses of 500 mg metformin delayed-release
Drug: Met DR
metformin delayed-release tablets

Experimental: 1000 mg Met DR BID
Two doses of 1000 mg metformin delayed-release
Drug: Met DR
metformin delayed-release tablets

Active Comparator: 1000 mg Met IR BID
Two doses of 1000 mg metformin immediate-release
Drug: Met IR
metformin immediate-release tablets

Active Comparator: 2000 mg Met XR QD
Single dose of 2000 mg metformin extended-release
Drug: Met XR
metformin extended-release tablets




Primary Outcome Measures :
  1. AUC (0-t) of Plasma Metformin [ Time Frame: Time points to create AUC (0-t) were: t = -0.08, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, 10, 11, 11.92, 12.5, 13, 13.5, 14, 14.5, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 hours relative to the start time of the standardized dinner. ]
    AUC (0-t) = Area under the curve from the time of dosing (0 h) to the time of the last quantifiable concentration after the standardized dinner. Doses were administered 1 min prior to 0 h (standardized dinner) for once daily in the evening (qPM) and twice daily (BID) dosing and 1 min prior to 12 h (standardized breakfast) for once daily in the morning (qAM) and BID dosing.

  2. Cmax of Plasma Metformin [ Time Frame: Time points to create Cmax were: t = -0.08, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, 10, 11, 11.92, 12.5, 13, 13.5, 14, 14.5, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 hours relative to the start time of the standardized dinner. ]
    Cmax = Maximum concentration from the first dose of study medication administration (0 h) to the time of the last quantifiable concentration following dose administration. Doses were administered 1 min prior to 0 h (standardized dinner) for qPM and BID dosing and 1 min prior to 12 h (standardized breakfast) for qAM and BID dosing.



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Ages Eligible for Study:   19 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. 19 to 65 (inclusive) years old at Visit 1 (Screening)
  2. Male, or if female and met all of the following criteria:

    1. Not breastfeeding
    2. Negative pregnancy test result at Visit 1 (Screening) (not applicable to hysterectomized females)
    3. Surgically sterile, postmenopausal, or if of childbearing potential, practiced and was willing to continue to practice appropriate birth control during the entire duration of the study
  3. Body mass index (BMI) of 25.0 to 35.0 kg/m² (inclusive) at Visit 1 (Screening)
  4. Had a physical examination with no clinically significant abnormalities as judged by the investigator
  5. Had normal renal function with an estimated glomerular filtration rate (eGFR) ≥90 mL/min/1.73 m² based on the Modification of Diet in Renal Disease (MDRD) equation
  6. Ability to understand and willingness to adhere to protocol requirements

Exclusion Criteria:

  1. Had a clinically significant medical condition as judged by the investigator that could potentially affect study participation and/or personal well-being, including but not limited to the following conditions:

    1. Hepatic disease
    2. Gastrointestinal disease
    3. Endocrine disorder (including diabetes and impaired glucose tolerance)
    4. Cardiovascular disease
    5. Central nervous system diseases
    6. Psychiatric or neurological disorders
    7. Organ transplantation
    8. Chronic or acute infection
    9. Orthostatic hypotension, fainting spells or blackouts
    10. Allergy or hypersensitivity
  2. Had any chronic disease requiring medication that was adjusted in the past 90 days (subjects could take acute intermittent over-the-counter medications such as Tylenol, if needed)
  3. Had major surgery of any kind within 6 months of Visit 1 (Screening)
  4. Had a history of >6 kg weight change within 3 months of Visit 1 (Screening)
  5. Had clinical laboratory test (clinical chemistry, hematology, or urinalysis) abnormalities judged by the investigator to be clinically significant at Visit 1 (Screening)
  6. Had a physical, psychological, or historical finding that, in the investigator's opinion, would make the subject unsuitable for the study
  7. Had any drug treatment that affects gastric pH (prescription or over-the-counter), including any antacids or medications such as Rolaids or Pepcid within 2 days of Visit 1 (Screening)
  8. Currently abused drugs or alcohol or had a history of abuse that in the investigator's opinion would cause the individual to be noncompliant with study procedures
  9. Smoked more than 10 cigarettes per day, 3 cigars per day, 3 pipes per day, used more than 1 can of smokeless tobacco per week, or used a combination of tobacco products that approximate nicotine doses equivalent to 10 cigarettes per day
  10. Had donated blood within 3 months of the date of the first dose of randomized study medication, or was planning to donate blood during the study
  11. Had received any investigational drug within 2 months (or five half-lives of the investigational drug, whichever was greater) of the date of the first dose of randomized study medication
  12. Had known allergies or hypersensitivity to any component of study treatment
  13. Was employed by Elcelyx Therapeutics, Inc (that is an employee, temporary contract worker, or designee of the company)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02291510


Sponsors and Collaborators
Elcelyx Therapeutics, Inc.
Investigators
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Principal Investigator: Scott Rasmussen, MD Celerion

Publications:
DeFronzo RA, Buse JB, Kim T, Skare S, Baron A, Fineman M, editors. Dissociation between Metformin Plasma Exposure and its Glucose-Lowering Effect: A Novel Gut-Mediated Mechanism of Action. 73rd Annual Scientific Meeting of The American Diabetes Association; 2013 June 21-25th; Chicago, Il.

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Responsible Party: Elcelyx Therapeutics, Inc.
ClinicalTrials.gov Identifier: NCT02291510     History of Changes
Other Study ID Numbers: LCRM103
First Posted: November 14, 2014    Key Record Dates
Results First Posted: September 21, 2015
Last Update Posted: December 2, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
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Metformin
Hypoglycemic Agents
Physiological Effects of Drugs