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Examining Endogenous Antioxidant Levels in Well Trained Cyclists

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ClinicalTrials.gov Identifier: NCT02281851
Recruitment Status : Unknown
Verified October 2014 by University of Birmingham.
Recruitment status was:  Recruiting
First Posted : November 4, 2014
Last Update Posted : November 4, 2014
Sponsor:
Information provided by (Responsible Party):
University of Birmingham

Brief Summary:
This study will investigate whether increased habitual intake of antioxidant supplements effects the concentration of endogenous antioxidants, the response of antioxidants to exercise, and differences in oxidative damage compared to a non-supplemented group.

Condition or disease
Oxidative Stress

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case Control
Official Title: The Effects of Habitual Antioxidant Supplementation on Endogenous Antioxidants and Oxidative Damage in Well Trained Cyclists
Study Start Date : July 2013
Estimated Primary Completion Date : May 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants

Group/Cohort
Supplemented
The group consists of well-trained cyclists who habitually consume vitamin/antioxidant supplements for a period longer than 6 months
Non-supplemented
The group consists of well-trained cyclists who do not consume vitamin/antioxidant supplements



Primary Outcome Measures :
  1. Difference in resting levels of endogenous antioxidant proteins in skeletal muscle [ Time Frame: Protein concentrations will be measured at baseline only ]
    To examine the effects of habitual vitamin and antioxidant supplementation on endogenous antioxidant production, participants will have a muscle biopsy taken at rest to examine any differences in endogenous antioxidant protein concentrations



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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Cyclist from the local West Midlands (United Kingdom) area will be invited to take part in the study.
Criteria

Inclusion Criteria:

  • Male,
  • BMI 18.8 29.9 kg/m2
  • cycle 3-7 times a week for durations longer than 60 minutes
  • cycled for a minimum of 3 years
  • accustomed to exhaustive cycling protocols
  • healthy (no known cardiovascular or metabolic disease)

Exclusion Criteria:

  • answering "NO" to any question on the general health questionnaire would result in exclusion from the study
  • current participation in another clinical study
  • current or recent smoker (last 30 days)
  • prescription or non-prescription of anti-inflammatory use >30 days prior to the experiment commencing or any other medications that in the opinion of the investigator may interfere with redox signalling

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02281851


Contacts
Contact: Matthew Soden, BSc +44 (0) 7800549318 mxs955@bham.ac.uk

Locations
United Kingdom
School of Sport Exercise and Rehabilitation Sciences, University of Birmingham Recruiting
Birmingham, West Midlands, United Kingdom, B15 2TT
Contact: Matthew Soden, BSc    +44 (0) 7800549318    mxs955@bham.ac.uk   
Sub-Investigator: Matthew Soden, BSc         
Principal Investigator: Sarah Aldred, MSc PhD         
Sponsors and Collaborators
University of Birmingham
Investigators
Principal Investigator: Sarah Aldred, MSc PhD University of Birmingham

Responsible Party: University of Birmingham
ClinicalTrials.gov Identifier: NCT02281851     History of Changes
Other Study ID Numbers: 125663
13/WM/0226 ( Other Identifier: NRES Committee West Midlands - Solihull )
First Posted: November 4, 2014    Key Record Dates
Last Update Posted: November 4, 2014
Last Verified: October 2014

Keywords provided by University of Birmingham:
Endogenous antioxidants
Antioxidant supplements
Vitamin Supplements
Exercise adaptations
Oxidative stress
Redox regulation
Cycling - exercise

Additional relevant MeSH terms:
Vitamins
Antioxidants
Micronutrients
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents