Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
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|ClinicalTrials.gov Identifier: NCT02272660|
Recruitment Status : Completed
First Posted : October 23, 2014
Last Update Posted : August 28, 2015
|Condition or disease||Intervention/treatment||Phase|
|Pain, Postoperative||Drug: Parecoxib sodium Drug: Normal saline injection||Phase 4|
Non-steroid anti-inflammatory drugs are recommended for multimodal postoperative pain management.
We evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||74 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Perioperative Parecoxib Administration for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty-A Randomized, Placebo-controlled Trial|
|Study Start Date :||October 2014|
|Actual Primary Completion Date :||August 2015|
|Actual Study Completion Date :||August 2015|
Experimental: Parecoxib sodium
The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision.
Drug: Parecoxib sodium
The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.
Other Name: Dynastat
Placebo Comparator: Normal saline injection
The control group received 2 mL normal saline injection at the same time point.
Drug: Normal saline injection
The patients in the control group received 2 mL normal saline injection 30 minutes before Normal saline injection incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.
Other Name: Physiological saline
- To evaluate the Morphine consumption in each group patients [ Time Frame: 4 hours to 6 days after the surgery ]
- To evaluate Patient-Controlled Intravenous Analgesia (PCIA) duration [ Time Frame: 4 hours to 6 days after the surgery ]
- To evaluate the Visual Analog Scale (VAS) in each group patients underwent total knee arthroplasty and total hip arthroplasty [ Time Frame: 4 hours to 6 days after the surgery ]
- Function recovery of knee Range of Motion (ROM) for patients received surgery [ Time Frame: 3 and 6 days after the surgery ]
- Testing of body temperature,routine blood examination, IL-6 and IL-10 [ Time Frame: hospital admission and 1, 3, 6 days after the surgery ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02272660
|The Peking Union Medical College Hospital|
|Beijing, Beijing, China, 100005|
|Principal Investigator:||Zhihong Wu, Prof||PUMC|