Respiratory Muscles and Inspiratory Muscle Training (IMT)
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|ClinicalTrials.gov Identifier: NCT02243527|
Recruitment Status : Completed
First Posted : September 18, 2014
Results First Posted : July 4, 2019
Last Update Posted : July 4, 2019
The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.
This study will look at how someone breathes can change after IMT. Understanding how IMT changes the body can help us use IMT in different treatments.
|Condition or disease||Intervention/treatment||Phase|
|Respiratory Muscles Breathing Exercises||Other: Inspiratory Muscle Training Other: Sham Inspiratory Muscle Training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||25 participants|
|Intervention Model:||Parallel Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Inspiratory Muscle Training on Respiratory Muscle Mechanics and Haemodynamics in Healthy Adults|
|Study Start Date :||September 2014|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
|Experimental: Inspiratory Muscle Training||
Other: Inspiratory Muscle Training
6-weeks of inspiratory muscle training
Sham Comparator: Sham-Control Inspiratory Muscle Training
Inspiratory muscle training at a low intensity meant to elicit no physiological changes.
Other: Sham Inspiratory Muscle Training
A sham training procedure that is meant to elicit no physiologic changes
- Diaphragm Electromyography [ Time Frame: Post Intervention - ie. immediately after 5 weeks of inspiratory muscle training ]
Using a multipair esophageal electrode catheter we will determine any changes to the electric activity of the diaphragm.
Diaphragm electromyography (EMG) has been expressed as %max. This unit is determined as the ratio of average EMG value (uV) divided by the maximal EMG activity (uV) generated during a maximal respiratory maneuver (inspiratory capacity during exercise).
- Accessory Respiratory Muscle Activation [ Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training ]
Using surface electromyography to determine the activation patterns of accessory respiratory muscles (scalene and sternocleidomastoid).
Data are expressed as %max. This value is determined by taking the average electromyography (EMG) activity divided by the maximal EMG activity generated during a maximal inspiratory maneuver (inspiratory capacity during exercise).
- Dyspnoea [ Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training ]
Using the modified Borg scale to assess changes in perceived dyspnoea after inspiratory muscle training.
The modified Borg scale is a 0-10 category ratio scale. The floor (0) of the scale is anchored subjectively to the subjects interpretation of "no breathing discomfort at all", and the ceiling (10) to represent "the most intense breathing discomfort they have experienced or could imagine experiencing".
- Muscle Oxygenation [ Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training ]Using near-infrared spectroscopy to examine if there are any relative changes in concentration (∆umol/Litre) of deoxygenated hemoglobin (HHb) after training. Deoxygenated hemoglobin is used as a surrogate of oxygen extraction specific to the local vasculature of the vastus lateralis,
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02243527
|Canada, British Columbia|
|Centre for Heart Lung Innovation|
|Vancouver, British Columbia, Canada, V6Z 1Y6|
|Principal Investigator:||Jordan A Guenette, PhD||University of British Columbia/Centre for Heart Lung Innovation|