The Effect of Exercise Training on Cardiac Structure and Function
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|ClinicalTrials.gov Identifier: NCT02224495|
Recruitment Status : Completed
First Posted : August 25, 2014
Last Update Posted : August 25, 2014
Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease. Other cardiovascular and non-cardiovascular benefits have been reported, namely in glucose metabolism, skeletal muscle function, oxidative stress, vascular function, pulmonary circulation, ischaemia-reperfusion lesion and ventricular remodelling.
However, the benefit of exercise training on systolic and diastolic function is controversial especially after acute myocardial infarction where no longitudinal study has evaluated diastolic function using modern echocardiographic parameters.
The hypothesis is that a structured program of exercise training can improve systolic and diastolic function in patients after myocardial infarction.
|Condition or disease||Intervention/treatment||Phase|
|Myocardial Infarction||Behavioral: Structured exercise training||Phase 1 Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||200 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effect of Exercise Training on Cardiac Structure and Function|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||May 2013|
Placebo Comparator: Control
Standard of care
Experimental: Structured exercise training
8-week outpatient exercise-training program, encompassing 3 sessions per week, including endurance and resistance training
Behavioral: Structured exercise training
- Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity) [ Time Frame: 4 months ]Determined by echocardiography; results in cm/s
- Ratio between early diastolic filling velocity from mitral inflow and myocardial early diastolic velocity at mitral annulus by tissue Doppler (E/E' ratio) [ Time Frame: 4 months ]Determined by echocardiography; no unit (ratio)
- Myocardial systolic velocity at mitral annulus by tissue Doppler (S' velocity) [ Time Frame: 4 months ]Determined by echocardiography; results in cm/s
- Left ventriclular ejection fraction [ Time Frame: 4 months ]Determined by echocardiography; results in %
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02224495
|Cardiology Department Gaia Hospital Center|
|Gaia, Portugal, 4450-189|
|Study Director:||Adelino Leite-Moreira, PhD||Universidade do Porto|