Alternative Antibiotic Regime in the Treatment of GAgP
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|ClinicalTrials.gov Identifier: NCT02223702|
Recruitment Status : Completed
First Posted : August 22, 2014
Results First Posted : November 2, 2018
Last Update Posted : November 2, 2018
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in 6-month follow-up.
A total of 40 systemically healthy patients with GAgP will evaluate in this randomized clinical trial. Periodontal parameters (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) will be recorded at baseline, 1st, 3rd and 6th month. Patients will receive either 400 mg moxifloxacin per os once daily or 500 mg metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.
|Condition or disease||Intervention/treatment||Phase|
|Generalized Aggressive Periodontitis Aggressive Periodontitis||Drug: Amoxicillin Drug: Metronidazole Drug: Moxifloxacin||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||39 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Investigator, Outcomes Assessor)|
|Primary Purpose:||Supportive Care|
|Official Title:||Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial|
|Study Start Date :||May 2011|
|Actual Primary Completion Date :||May 2012|
|Actual Study Completion Date :||July 2014|
Active Comparator: amoxicillin+metronidazole
amoxicillin+metronidazole group received a combination of 500 mg of amoxicillin and 500 mg metronidazole three times per day for 7 days.
500 mg, 3 times per day for 7 days
Other Name: largopen
500 mg, 3 times per day, for 7 days
Other Name: flagyl
The moxifloxacin group received 400 mg moxifloxacin, once in a day for 7 days.
400 mg, once in a day for 7 days.
Other Name: pitoxil
- The Primary Outcome Variable Was Probing Depth. [ Time Frame: 6-months ]We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups.
- The Attachment Loss Were Considered as a Secondary Measure. [ Time Frame: 6-months ]Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02223702
|Kocaeli University Faculty of Dentistry Department of Periodontology|
|Kocaeli, Turkey, 41190|
|Principal Investigator:||Esra Guzeldemir-Akcakanat||Kocaeli University|