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Verticality Perception - Multisensory Contribution

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ClinicalTrials.gov Identifier: NCT02212704
Recruitment Status : Completed
First Posted : August 8, 2014
Last Update Posted : December 2, 2015
Sponsor:
Information provided by (Responsible Party):
University of Zurich

Brief Summary:
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Condition or disease Intervention/treatment Phase
Verticality Perception in Healthy Human Subjects Individual Contribution of Different Sensory Systems Other: Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk) Other: 3D-video-head impulse testing Other: Vestibular-evoked myogenic potentials (VEMPs) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects
Study Start Date : October 2014
Actual Primary Completion Date : November 2015
Actual Study Completion Date : November 2015

Arm Intervention/treatment
Experimental: Vestibular stimulation
This is the experimental paradigm applied in all participants
Other: Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)
Other: 3D-video-head impulse testing
Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

Other: Vestibular-evoked myogenic potentials (VEMPs)
Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study




Primary Outcome Measures :
  1. Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions [ Time Frame: During the turntable measurement (90 minutes) ]

Secondary Outcome Measures :
  1. relative contribution of head- and trunk-based sensory systems based on Bayesian modelling [ Time Frame: while on the turntable (1.5 hours) ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • ages 18-60 years
  • informed consent
  • absence of exclusion criteria

Exclusion Criteria:

  • peripheral-vestibular deficit
  • disturbed consciousness
  • history of sensory deficits
  • visual field deficits
  • other neurological or systemic disorder which can cause dementia or cognitive dysfunction
  • intake of antidepressants, sedatives, or neuroleptics
  • pregnancy, unless excluded by a negative pregnancy test
  • known neck pain or status post neck trauma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02212704


Locations
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Switzerland
University Hospital Zurich, Dept. of Neurology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Investigators
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Principal Investigator: Dominik Straumann, Prof, MD University Hospital Zurich, Dept. of Neurology

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Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT02212704    
Other Study ID Numbers: perception_head_roll_zurich
First Posted: August 8, 2014    Key Record Dates
Last Update Posted: December 2, 2015
Last Verified: December 2015
Keywords provided by University of Zurich:
vestibular
proprioception
spatial orientation
bayesian