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Adaptive Cognitive Training in Healthy Older Adults

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02205710
Recruitment Status : Completed
First Posted : July 31, 2014
Last Update Posted : August 2, 2019
Sponsor:
Collaborator:
University of Ottawa
Information provided by (Responsible Party):
Bruyere Research Institute

Brief Summary:
Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.

Condition or disease Intervention/treatment Phase
Mild Cognitive Impairment Mild to Moderate Dementia Alzheimer's Disease Other: Computerized cognitive training Other: Computerized games Not Applicable

Detailed Description:
The study involves 25 sessions of an adaptive cognitive training program, completed over 5 weeks. Pre and post training assessments will evaluate any near and far transfer effects of training.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 99 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Other
Official Title: Adaptive Cognitive Training in Healthy Older Adults
Study Start Date : August 2016
Actual Primary Completion Date : August 2018
Actual Study Completion Date : August 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Computerized cognitive training
Series of gamified tasks.
Other: Computerized cognitive training
Other Name: Activate

Placebo Comparator: Computerized game training
Series of gamified tasks.
Other: Computerized games



Primary Outcome Measures :
  1. Change in ratings on cognitive training survey [ Time Frame: Baseline, week 5 ]
    This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.

  2. Change in neural activity [ Time Frame: Baseline, week 5 ]
    We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.

  3. Change in performance on neuropsychological tests [ Time Frame: Baseline, week 5 ]
    Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.


Secondary Outcome Measures :
  1. Change in ratings of psychological wellbeing [ Time Frame: Baseline, week 5 ]
    We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing.



Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • English as the maternal or primary spoken language.
  • Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease).
  • Normal or corrected-to-normal vision and hearing.

Exclusion Criteria:

  • Poor hearing or vision
  • Inadequate understanding of the English language

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02205710


Locations
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Canada, Ontario
Bruyere Continuing Care
Ottawa, Ontario, Canada, K1N 5C8
Sponsors and Collaborators
Bruyere Research Institute
University of Ottawa
Investigators
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Principal Investigator: Patrick Davidson, PhD University of Ottawa
Study Director: Sheida Rabipour, MSc University of Ottawa
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Responsible Party: Bruyere Research Institute
ClinicalTrials.gov Identifier: NCT02205710    
Other Study ID Numbers: M16-14-018
First Posted: July 31, 2014    Key Record Dates
Last Update Posted: August 2, 2019
Last Verified: August 2017
Additional relevant MeSH terms:
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Alzheimer Disease
Cognitive Dysfunction
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Cognition Disorders