Is Obstructive Sleep Apnoea a Risk Factor for Thoracic Aortic Aneurysm Expansion? A Prospective Cohort Study.
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02204774 |
Recruitment Status :
Active, not recruiting
First Posted : July 30, 2014
Last Update Posted : July 12, 2019
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Aortic Aneurysm Obstructive Sleep Apnea |

Study Type : | Observational |
Estimated Enrollment : | 230 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Is Obstructive Sleep Apnoea a Risk Factor for Thoracic Aortic Aneurysm Expansion? A Prospective Cohort Study. |
Study Start Date : | July 2014 |
Estimated Primary Completion Date : | December 2019 |
Estimated Study Completion Date : | December 2019 |

Group/Cohort |
---|
Dilatated or aneurysmatic Aorta
Complete cohort, which will be followed over 3 years
|
- Aneurysm expansion rate [ Time Frame: three years ]mm per year
- combined endpoint of operation (or fulfilling the criteria for operation) [ Time Frame: three years ]Operation
- endovascular repair because of rapid progression of thoracic aortic aneurysm [ Time Frame: three years ]>10 mm per year and/or an aneurysm diameter >50 to 60 mm
- Death from proven or presumed aortic dissection/rupture [ Time Frame: three years ]Death

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Diagnosis of thoracic aortic aneurysm defined by the following parameters
- Women: at the level of the sinus of valsalva >39mm, or ascending aorta >42mm.
- Men: at the level of the sinus of valsalva >44mm, or ascending aorta >46mm.
Inclusion criteria:
-
Diagnosis of thoracic aortic aneurysm defined by the following parameters
- Women: at the level of the sinus of valsalva >39mm, or ascending aorta >42mm.
- Men: at the level of the sinus of valsalva >44mm, or ascending aorta >46mm.
- Age > 18 years.
Exclusion Criteria:
- Patients on continuous positive airway pressure (CPAP) therapy for OSA at baseline.
- Patients with known central sleep apnoea.
- Patients on morphine or other opioid medication, heroin addiction, alcohol addiction.
- Patients with moderate or severe aortic regurgitation.
- Patients with moderate or severe aortic stenosis.
- Pregnant patients.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02204774
Switzerland | |
University Hospital Zurich, Pneumology | |
Zürich, Switzerland, 8091 |
Study Director: | Malcolm Kohler, MD | Universuty of Zurich |
Responsible Party: | Malcolm Kohler, Head, Division of Pneumology, University of Zurich |
ClinicalTrials.gov Identifier: | NCT02204774 History of Changes |
Obsolete Identifiers: | NCT02162108 |
Other Study ID Numbers: |
V 1.1 |
First Posted: | July 30, 2014 Key Record Dates |
Last Update Posted: | July 12, 2019 |
Last Verified: | July 2019 |
aortic aneurysm obstructive sleep apnea |
Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Aneurysm Aortic Aneurysm Aortic Aneurysm, Thoracic Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory |
Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases Vascular Diseases Cardiovascular Diseases Aortic Diseases |