Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)
|ClinicalTrials.gov Identifier: NCT02196870|
Recruitment Status : Completed
First Posted : July 22, 2014
Last Update Posted : June 24, 2015
|Condition or disease|
|Airway Pressure Stress Index Transpulmonary Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance|
Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.
The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||12 participants|
|Observational Model:||Case Control|
|Target Follow-Up Duration:||3 Years|
|Official Title:||Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure|
|Study Start Date :||July 2014|
|Primary Completion Date :||June 2015|
|Study Completion Date :||June 2015|
- Changes of oxygenation and lung mechanics [ Time Frame: up to 24 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02196870
|Nanjing, Jiangsu, China, 210009|
|Principal Investigator:||Jianfeng Xie, Dr.||Zhongda hospital, Southeast University, Jiangsu, China|