Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke. (Pacific)
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|ClinicalTrials.gov Identifier: NCT02180542|
Recruitment Status : Completed
First Posted : July 2, 2014
Last Update Posted : October 11, 2017
The purpose of this study is to improve secondary prevention of ischemic stroke patients by
- Estimating prevalence and the prognostic significance of frequent premature atrial complexes in ischemic stroke patients in relation to death, recurrent stroke and atrial fibrillation.
Characterize ischemic stroke patients by
- Echocardiographic characteristics
- Biochemical markers
Plaque composition in the carotid arteries
- in order to improve risk stratification.
|Condition or disease|
|Stroke Atrial Fibrillation Premature Atrial Complexes|
Patients with atrial fibrillation (AF) have a five-fold increased risk of ischemic stroke compared to the general population. Identifying AF can be challenging, but prolonged rhythm monitoring of ischemic stroke patients have shown to enhance detection rates of AF. Therefore it is important to identify predictors of AF to allow targeted screening of patients after ischemic stroke and thereby reduce the recurrent stroke rate. Few former studies have shown an association between excessive numbers of premature atrial complexes (PACs) and AF.
The study population of ischemic stroke patients will at admission undergo following examinations:
- 48 hours inpatient cardiac telemetry (If not known AF)
- 24 hours holter monitoring (if not known AF)
- blood sample
- CT scan of carotid arteries with contrast made on Dual Energy CT scan.
In the follow-up period, patients will have two visits with 48 hour holter monitoring (after 6 and 12 months, respectively) It will be noticed if patients have any recurrent events, die og developing AF.
The study population will be divided into four groups as follows:
- patients with new AF at admission
- patients with known AF
- patients with frequent PACs
- patients without frequent PACs. These groups will be compared on baseline characteristics and on outcome as mentioned.
The overall perspective is to make better strategies for detecting occult AF after ischemic stroke to improve secondary stroke prevention care.
|Study Type :||Observational|
|Actual Enrollment :||264 participants|
|Official Title:||Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke: Prevalence, Characteristics and Prognosis|
|Study Start Date :||March 2012|
|Actual Primary Completion Date :||August 2015|
|Actual Study Completion Date :||October 2016|
Ischemic stroke patients
Patients admitted with ischemic stroke from march 2012 to april 2014
- time to death and recurrent stroke [ Time Frame: Up to 4 years ]
- Time to death, recurrent stroke and atrial fibrillation [ Time Frame: Up to 4 years ]
- Left atrial volume and function estimated by echocardiography [ Time Frame: baseline ]descriptive comparison in between groups.
- biochemical markers [ Time Frame: baseline ]descriptive comparison in between groups
- Plaque analysis i the carotid arteries on CT [ Time Frame: baseline ]descriptive comparison in between groups.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02180542
|Department of Medical Research, OUH, Svendborg|
|Svendborg, Funen, Denmark, 5700|
|Principal Investigator:||Kristina H Vinther, MD|