The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
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|ClinicalTrials.gov Identifier: NCT02149628|
Recruitment Status : Completed
First Posted : May 29, 2014
Last Update Posted : July 29, 2015
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.
Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.
To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.
Secondarily, kidney protection effect of propofol over desflurane will be compared.
|Condition or disease||Intervention/treatment||Phase|
|Prostate Cancer||Drug: propofol Drug: Desflurane||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery|
|Study Start Date :||May 2014|
|Primary Completion Date :||February 2015|
|Study Completion Date :||February 2015|
Active Comparator: desflurane
use desflurane as a primary anesthetics during anesthesia guided by bispectral index (BIS)
propofol infusion with target-controlled infusion(TCI) device guided by BIS
Other Name: fresofol, 2%
- changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation [ Time Frame: 100 min after pneumoperitoneum, 10 min after decompression ]
- kidney function after anesthesia [ Time Frame: 1 day after operation ]measure creatinine
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02149628
|Korea, Republic of|
|Yonsei University, Gangnam Severance Hospital|
|Seoul, Korea, Republic of|
|Principal Investigator:||Goun Roh, MD||Yonsei University, Gangnam Severance Hospital|