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Yoga as an Intervention for Women With Knee Osteoarthritis

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ClinicalTrials.gov Identifier: NCT02146105
Recruitment Status : Completed
First Posted : May 23, 2014
Results First Posted : February 19, 2015
Last Update Posted : September 26, 2017
Sponsor:
Information provided by (Responsible Party):
McMaster University

Brief Summary:
Keeping individuals with knee osteoarthritis physically active is critically important. Exercise is effective at reducing pain while improving physical function. However some exercises can overload the knee, and as a result, worsen knee pain and health of the knee joint. Yoga offers a foundation of static postures that improve muscle strength and joint flexibility. Using sophisticated technology that allows us to calculate the loads inside the knee, the investigators have selected yoga exercises that do not overload the knee joint. The investigators have designed a yoga exercise class that is ideal for people with knee osteoarthritis. The purpose of the study is to investigate whether these yoga exercises increase muscle strength and reduce knee pain in women with knee osteoarthritis. In addition, the investigators aim to show that these yoga exercises will also improve knee loads during activities, mobility and heart health. The investigators will ask 50 women with knee osteoarthritis to participate in a 12 week yoga exercise intervention, that requires attendance to 3 classes each week. The investigators will test strength of the leg muscles, pain, knee joint loads, mobility and cardiovascular health before and after the 12 week yoga exercise intervention.

Condition or disease Intervention/treatment Phase
Osteoarthritis Other: Yoga For Knee Osteoarthritis Not Applicable

Detailed Description:
This study is an uncontrolled intervention study with repeated measures. The intervention is a 12-week supervised exercise class featuring biomechanically sound exercises for people with knee osteoarthritis. Measures of strength of the knee muscles, pain, biomechanics during walking and yoga, mobility and cardiovascular health will be included. Strength will be measured on a dynamometer. Pain will be assessed with questionnaires. Walking and three yoga postures will be observed using motion capture system integrated with force measurements from the floor. Mobility will be assessed during walking, stair-climbing and chair standing tasks. Cardiovascular health will be measured during a submaximal bicycle task.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 45 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Yoga Exercise Intervention Designed for Women With Knee Osteoarthritis
Study Start Date : May 2014
Actual Primary Completion Date : February 2015
Actual Study Completion Date : February 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Arm Intervention/treatment
Experimental: Yoga For Knee Osteoarthritis
An tailored arthritis-specific yoga program for women with knee osteoarthritis with the aim of increasing leg strength and alleviating knee pain related to the disease.
Other: Yoga For Knee Osteoarthritis
Yoga program specifically for women with knee osteoarthritis.




Primary Outcome Measures :
  1. Change in Knee Extensor Torque [ Time Frame: Week 1 and Week 13 ]
    Knee extensor torque (Newton*meter) is calculated on a Biodex dynamometer using an isometric protocol. Trials are completed as a voluntary maximum effort.

  2. Change in Knee Pain [ Time Frame: Week 1 and Week 13 ]
    Knee pain is assessed subjectively via the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaires.


Secondary Outcome Measures :
  1. Change in Six Minute Walk Test (6MWT) [ Time Frame: Week 1 and Week 13 ]
    Participants are asked to walk as far as possible for a total of six minutes at a self-selected pace in an obstruction-free rectangular hallway. Distance traveled is recorded in metres (m).

  2. Change in 30-second Chair Stand [ Time Frame: Week 1 and Week 13 ]
    Participants are asked to cross their arms over their chest and rise and sit back down in a chair as many times as possible in 30 seconds.

  3. Change in Timed Up and Go (TUG) [ Time Frame: Week 1 and Week 13 ]
    Participants are asked to raise from a standard chair, walk forward 3-metres until an orange cone is reached, walk around the cone, then walk back to the chair and sit down. The test is to be completed as quickly and safely as possible without running. The trial is repeated a second time and the quickest time (in seconds) is recorded.

  4. Change in Stair Ascent and Descent [ Time Frame: Week 1 and Week 13 ]
    Participants are asked to climb a standard flight of 9 stairs as quickly and safely as possible without compromising safety. Stair ascent and descent are assessed individually. Time to climb the stairs are recorded (in seconds) and averaged over two trials.

  5. Change in Subjective Scales [ Time Frame: Week 1 and Week 13 ]
    The Centre of Epidemiologic Studies Depression Scale (19-items), the Athens Insomnia Scale (8-items), and the Perceived Stress Scale (10-items) will be given to the participants to gather information on feelings of depression, sleeping patterns, and perceived stress, respectively.

  6. Change in Cardiovascular Fitness [ Time Frame: Week 1 and Week 13 ]
    Cardiovascular fitness is assessed using a sub maximal oxygen consumption cycle ergometer test. Heart rate is monitored using a Polar Heart Rate monitor and the test is terminated upon one of two conditions: a) volitional fatigue, or b) within 10 beats of 85% of the age-predicted maximum heart rate is achieved. Values are recorded in mL/kg/min.

  7. Change in Biomechanical Outcomes [ Time Frame: Week 1 and Week 13 ]
    Participants will be asked to partake in a complete kinematic, kinetic, and electromyographic analysis of gait and static postures using floor-embedded force plates, a 9-camera motion capture system, and a wireless electromyography system. Knee adduction moment (KAM; Nm/kg), normalized electromyography to a percentage of their maximal effort (%MVIC), and muscular co-activation (%) are the variables of interest.



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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Female - 50 years of age or older
  • Knee pain on most days of the week
  • Less than 30 minutes of morning stiffness
  • Bony enlargement
  • Bony tenderness to palpation
  • Signs of inflammation
  • Able to safely climb 2 flights of stairs without aid
  • Visited a family physician within the last 12 months

Exclusion Criteria:

  • Any other forms of arthritis
  • Osteoporosis
  • History of patellofemoral symptoms
  • Active non-arthritic knee disease
  • Knee surgery
  • Use of cane or walking aid
  • Unstable heart condition
  • Neurological conditions
  • Skin allergy to medical tape
  • Hip or ankle injuries in past 3 months
  • Any injuries that would prohibit participation in yoga
  • Ipsilateral hip or ankle conditions
  • Currently receiving cancer treatment
  • Currently pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02146105


Locations
Canada, Ontario
McMaster University
Hamilton, Ontario, Canada, L8P 3Y4
Sponsors and Collaborators
McMaster University
Investigators
Principal Investigator: Monica R Maly, PhD School of Rehabilitation Sciences, McMaster University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: McMaster University
ClinicalTrials.gov Identifier: NCT02146105     History of Changes
Other Study ID Numbers: Yoga_KneeOA
Labarge ( Other Grant/Funding Number: Labarge Optimal Aging Initiative )
First Posted: May 23, 2014    Key Record Dates
Results First Posted: February 19, 2015
Last Update Posted: September 26, 2017
Last Verified: August 2017

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases