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Bed-rest, Muscle Mass and Insulin Sensitivity

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ClinicalTrials.gov Identifier: NCT02109380
Recruitment Status : Completed
First Posted : April 9, 2014
Last Update Posted : April 28, 2015
Sponsor:
Information provided by (Responsible Party):
Lex Verdijk, Maastricht University Medical Center

Brief Summary:
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

Condition or disease Intervention/treatment Phase
Disuse Atrophy Behavioral: Bed rest Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men
Study Start Date : June 2014
Actual Primary Completion Date : April 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy
Drug Information available for: Insulin

Arm Intervention/treatment
Experimental: Bed rest
One week of bed rest.
Behavioral: Bed rest



Primary Outcome Measures :
  1. Change in quadriceps muscle cross-sectional area [ Time Frame: One day before and directly after cessation of bed rest. ]

Secondary Outcome Measures :
  1. Change in lower back cross-sectional area [ Time Frame: One day before and directly after cessation of bed rest. ]
  2. Change in leg and whole body lean tissue mass [ Time Frame: One day before and directly after cessation of bed rest. ]
  3. Change in muscle fiber size [ Time Frame: One day before and directly after cessation of bed rest. ]
  4. Change in muscle strength [ Time Frame: One day before and directly after cessation of bed rest. ]
    Measured by 1-Repetition Maximum testing

  5. Change in insulin sensitivity [ Time Frame: One day before and directly after cessation of bed rest. ]
    Measured by hyperinsulinemic-euglycemic clamp



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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Aged from 18-35 years
  • 18.5 < BMI < 30 kg/m2

Exclusion Criteria:

  • Smoking
  • Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
  • Hypertension (according to WHO criteria) and/or cardiovascular disease
  • Any back/leg/knee/neck/postural complaints
  • Use of any prescribed medication
  • Type 2 diabetes mellitus
  • Any family history of thrombosis
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
  • Myocardial infarction within the last 3 years
  • Use of anti-coagulants

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02109380


Locations
Netherlands
Maastricht University Medical Centre
Maastricht, Netherlands
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc JC van Loon, PhD Maastricht UMC

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Lex Verdijk, Assistant Professor, Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT02109380     History of Changes
Other Study ID Numbers: METC 14-3-013
First Posted: April 9, 2014    Key Record Dates
Last Update Posted: April 28, 2015
Last Verified: April 2015

Additional relevant MeSH terms:
Atrophy
Insulin Resistance
Muscular Disorders, Atrophic
Pathological Conditions, Anatomical
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Muscular Diseases
Musculoskeletal Diseases
Neuromuscular Diseases
Nervous System Diseases
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs