Comparison of Surveillance Colonoscopy Techniques in Patients With IBD
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02098798|
Recruitment Status : Completed
First Posted : March 28, 2014
Last Update Posted : August 17, 2016
We propose a randomized controlled study to determine the detection rates of neoplasia with high definition colonoscopy alone, high definition dye spraying chromoendoscopy or High definition iSCAN virtual chromoendoscopy in patients with long standing colitis (8 years from diagnosis except primary sclerosing cholangitis when surveillance starts at diagnosis) CD or UC.
We hypothesized that these novel endoscopic techniques using High definition colonoscopy with virtual chromoendoscopy -iScan 2 and 3 may be superior to high definition colonoscopy alone and similar to using dye spraying chromoendoscopy for detection of dysplasia and neoplasia in patients with long standing IBD.
We will aim to demonstrate if we can avoid dye spraying during the procedure and save expense and considerable time.
In addition, we can hope to produce evidence and inform the way in which we perform surveillance colonoscopy especially without large number of multiple random biopsies but only few targeted" smart and intelligent" biopsies using high definition colonoscopy with iSCAN technique as is already the European practice in several centres.
|Condition or disease||Intervention/treatment|
|Inflammatory Bowel Disease||Procedure: HD Colonoscopy Procedure: HD Colonoscopy + iSCAN Procedure: HD Colonoscopy + dye spray|
|Study Type :||Observational|
|Actual Enrollment :||270 participants|
|Study Start Date :||March 2014|
|Primary Completion Date :||April 2016|
|Study Completion Date :||August 2016|
High Definition Colonoscopy alone
Procedure: HD Colonoscopy
High definition colonoscopy procedure in surveillance colonoscopy
HD + iSCAN
HD colonoscopy + iSCAN
|Procedure: HD Colonoscopy + iSCAN|
HD + Dye
High definition colonoscopy + dye spraying chromoendoscopy
|Procedure: HD Colonoscopy + dye spray|
- Detection of neoplasia in the 3 cohorts - high definition colonoscopy, HD colonoscopy + iSCAN, HD colonoscopy + dye chromoendoscopy [ Time Frame: At the time of procedure ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02098798
|University of Calgary, Foothills Medical Centre|
|Calgary, Alberta, Canada, T2N 4N1|