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The Interaction Between Appetite Hormones

This study has been completed.
Sponsor:
Collaborator:
The Danish Medical Research Council
Information provided by (Responsible Party):
Signe Torekov, University of Copenhagen
ClinicalTrials.gov Identifier:
NCT02094183
First received: March 17, 2014
Last updated: July 4, 2014
Last verified: July 2014
  Purpose
Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change

Condition Intervention
Obesity
Other: GLP-1
Dietary Supplement: low calorie diet

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Interaction Between Appetite Hormones and Their Importance for Maintenance of Weight Loss After a Low Calorie Diet

Resource links provided by NLM:


Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • Change in hormone level corrected for weight change [ Time Frame: Baseline and week 52 ]

Enrollment: 58
Study Start Date: September 2011
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: GLP-1
GLP-1 and low calorie diet
Other: GLP-1
GLP-1
Dietary Supplement: low calorie diet
low calorie diet
Experimental: Control
low calorie diet
Dietary Supplement: low calorie diet
low calorie diet

Detailed Description:
Many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of GLP-1.
  Eligibility

Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI > 30 and < 40 (kg/m2)
  • Healthy

Exclusion Criteria:

  • Other known illness
  • Medicine that affects glucose- and lipid metabolism, appetite or food intake
  • Pregnancy
  • Breast feeding
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT02094183

Locations
Denmark
University of Copenhagen
Copenhagen, Denmark, 2200
Hvidovre University Hospital
Hvidovre, Denmark, 2650
Sponsors and Collaborators
University of Copenhagen
The Danish Medical Research Council
Investigators
Study Chair: Jens Holst, DMSCi University of Copenhagen
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Signe Torekov, Assistant professor, University of Copenhagen
ClinicalTrials.gov Identifier: NCT02094183     History of Changes
Other Study ID Numbers: H-4-2010-134
Study First Received: March 17, 2014
Last Updated: July 4, 2014

Additional relevant MeSH terms:
Hormones
Glucagon-Like Peptide 1
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Incretins

ClinicalTrials.gov processed this record on May 23, 2017