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The purpose of this study is to determine a relationship between a person's flora/bacteria in their gut (the intestinal microbiome) and their risk of cardiovascular disease. Investigators will look at inflammatory markers in the blood and also look at the genome of the bacteria in the gut.
Condition or disease
Coronary Artery Disease
Investigators will look at inflammatory markers in the blood and also look at the genome of the bacteria in the gut. This research is being done because Investigators believe that there is a connection between the way food is digested by a person's gut bacteria and the development of atherosclerosis (hardening of the arteries) and cardiovascular disease. The ultimate goal of this research is to eventually determine if changes to the gut bacteria can prevent cardiovascular disease or disease progression.
50 cc blood obtained during angiogram and used for Endothelial Progenitor Cells analysis using antibodies for inflammatory markers. Plasma collection will be done for antibody analysis. Buffy coats will be frozen and stored for future genetic analysis. [ Time Frame: Blood samples will be obtained during the diagnostic angiogram. ]
Secondary Outcome Measures :
Stool samples will be collected to compare the fecal microbiota of patients with mild, moderate and severe coronary artery disease. [ Time Frame: Two weeks after the angiogram ]
Biospecimen Retention: Samples With DNA
Blood (50 cc) and stool samples will be collected on consenting participants. Participants will have the option of allowing us to store samples for future research
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Consenting participants who are undergoing coronary angiography.
Anyone undergoing cardiac catheterization for suspected coronary artery disease over age 18.
Patients currently on long-term antibiotics who cannot stop them for at least 2 weeks prior to providing a stool sample.
Patients on chronic laxatives who cannot stop for at least 2 weeks prior to stool collection.
Patients on probiotics and cannot stop for 2 weeks prior to giving a stool sample (yogurt is ok).
Patients who are unable to provide a stool sample to Mayo Clinic utilizing Fed Ex overnight mail.
Patients who have had previous Coronary Artery Bypass Grafting procedure