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Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

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ClinicalTrials.gov Identifier: NCT02007304
Recruitment Status : Unknown
Verified December 2013 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : December 10, 2013
Last Update Posted : December 10, 2013
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: Eccentric exercise training Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Preventing Arterial Stiffening Effects Induced by Acute and Chronic Eccentric Exercise
Study Start Date : November 2012
Estimated Primary Completion Date : July 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Herbs
participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training
Behavioral: Eccentric exercise training
12 weeks of lower leg eccentric training

Placebo Comparator: Placebo
parcipants in this group will take placebo capsule containing microcrystalline cellulose
Behavioral: Eccentric exercise training
12 weeks of lower leg eccentric training




Primary Outcome Measures :
  1. Pulse Wave Velocity [ Time Frame: Before eccentric exercise and training ]
    PWV will be measured before, 6th week, 12th week of eccentric exercise training.

  2. Pulse Wave Velocity [ Time Frame: 6th week of eccentric exercise traininig ]
    PWV will be measured before, 6th week, 12th week of eccentric exercise training.

  3. Pulse Wave Velocity [ Time Frame: 12th week of eccentric exercise training ]
    PWV will be measured before, 6th week, 12th week of eccentric exercise training.


Secondary Outcome Measures :
  1. Blood pressure [ Time Frame: Before intervention ]
    Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention.

  2. Blood pressure [ Time Frame: 6th week of intervention ]
    Morning blood pressure will be measured before, 6th, and after 12 week of dietary and eccentric exercise intervention.

  3. Blood pressure [ Time Frame: 12th week of intervention ]
    Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention.



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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

-Healthy sedentary adults

Exclusion Criteria:

  • obesity (BMI >30 kg/m2)
  • smoking within past six months
  • hypertension (high blood pressure >140/90 mmHg)
  • personal history of diabetes (fasting blood glucose >126 mg/dL), heart disease, or other cardiovascular problems
  • orthopedic injury that may prevent him or her from completing the exercise
  • the use of over-the-counter supplements or vitamins

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02007304


Contacts
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Contact: Hsin-Fu Lin, Ph.D. +886932873163 hsinfu@ntu.edu.tw

Locations
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Taiwan
National Taiwan University Recruiting
Taipei, Taiwan, 106
Contact: Hsin-Fu Lin, Ph.D    +886932873163    hsinfu@ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Hsin-Fu Lin, Ph.D National Taiwan University