The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
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|ClinicalTrials.gov Identifier: NCT01995760|
Recruitment Status : Completed
First Posted : November 27, 2013
Last Update Posted : September 4, 2014
|Condition or disease|
|Methicillin-resistant Staphylococcus Aureus Septicemia|
Several studies have shown AUC/MIC to be the better pharmacokinetic-pharmacodynamic parameter for clinical effectiveness of vancomycin. However, the 2009 consensus guideline for vancomycin therapeutic monitoring continued to recommend trough serum concentration monitoring in the clinical setting. In 2011, Patel et al showed that highly difference between AUC(72-96h) and Cmin(96h). Different dosing and creatinine clearance may reach the same trough drug level with different AUC. The investigators wonder whether trough drug level can serve as a substitute marker for AUC and as a parameter for vancomycin therapeutic monitoring.
In this study, the investigators will calculate AUC/MIC of vancomycin with published formula, analyze its correlation with patient's clinical outcome and compare that with trough drug level.
|Study Type :||Observational|
|Actual Enrollment :||123 participants|
|Official Title:||The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?|
|Study Start Date :||November 2013|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||June 2014|
- 30-day mortality [ Time Frame: Day 30 after index date (the date of positive methicillin-resistant Staphylococcus aureus blood culture) ]
- 90-day mortality [ Time Frame: Day 90 after index date (the date of positive methicillin-resistant Staphylococcus aureus blood culture) ]
- In-hospital mortality [ Time Frame: Discharge day ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01995760
|National Taiwan University Hospital|
|Principal Investigator:||Li-Jiuan Shen||National Taiwan University Hospital|