A Phase 1 Study of IMGN289 in Adult Patients With EGFR-positive Solid Tumors
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
18 years old at time of consent
Diagnosed with a solid tumor that has progressed despite standard therapy or for which no standard effective or curative options exist or are suitable
EGFR-positive tumor expression
Adequate blood and organ function
Must agree to use contraception while on study and for 12 weeks after the last dose of IMGN289 as applicable
Must be willing and able to sign informed consent and follow the study schedule and other protocol requirements
Other anti-cancer treatment during the study
Symptomatic brain metastases
Other clinically significant disease as defined by the protocol
Chronic skin condition that requires prescribed oral or intravenous treatment
History of severe rash that required discontinuation of prior EGFR targeted therapy
Receiving therapeutic doses of warfarin or heparin for anti-coagulation